Journal article
A cortical injury model in a non-human primate to assess execution of reach and grasp actions: implications for recovery after traumatic brain injury
Journal of neuroscience methods, Vol.361, pp.109283-109283
09/01/2021
DOI: 10.1016/j.jneumeth.2021.109283
PMCID: PMC9969347
PMID: 34237383
Abstract
Technological advances in developing experimentally controlled models of traumatic brain injury (TBI) are prevalent in rodent models and these models have proven invaluable in characterizing temporal changes in brain and behavior after trauma. To date no long-term studies in non-human primates (NHPs) have been published using an experimentally controlled impact device to follow behavioral performance over time.
We have employed a controlled cortical impact (CCI) device to create a focal contusion to the hand area in primary motor cortex (M1) of three New World monkeys to characterize changes in reach and grasp function assessed for 3 months after the injury.
The CCI destroyed most of M1 hand representation reducing grey matter by 9.6 mm3, 12.9 mm3, and 15.5 mm3 and underlying corona radiata by 7.4 mm3, 6.9 mm3, and 5.6 mm3 respectively. Impaired motor function was confined to the hand contralateral to the injury. Gross hand-use was only mildly affected during the first few days of observation after injury while activity requiring skilled use of the hand was impaired over three months.
This study is unique in establishing a CCI model of TBI in an NHP resulting in persistent impairments in motor function evident in volitional use of the hand.
Establishing an NHP model of TBI is essential to extend current rodent models to the complex neural architecture of the primate brain. Moving forward this model can be used to investigate novel therapeutic interventions to improve or restore impaired motor function after trauma.
•First nonhuman primate model of controlled cortical impact assessing motor recovery.•A grip device was developed and programed in Lab View to assess sustained grip.•Motor impairment was more pronounced for skilled use of digits than sustained grip.
Details
- Title: Subtitle
- A cortical injury model in a non-human primate to assess execution of reach and grasp actions: implications for recovery after traumatic brain injury
- Creators
- Scott Barbay - University of Kansas Medical CenterHongyu Zhang - University of Kansas Medical CenterShawn B. Frost - University of Kansas Medical CenterJeremy C. Peterson - University of KansasDavid J. Guggenmos - University of Kansas Medical CenterHeather M. Hudson - University of Kansas Medical CenterDavid T. Bundy - University of Kansas Medical CenterStacey L. DeJong - University of KansasRandolph J. Nudo - University of Kansas Medical Center
- Resource Type
- Journal article
- Publication Details
- Journal of neuroscience methods, Vol.361, pp.109283-109283
- Publisher
- Elsevier B.V
- DOI
- 10.1016/j.jneumeth.2021.109283
- PMID
- 34237383
- PMCID
- PMC9969347
- ISSN
- 0165-0270
- eISSN
- 1872-678X
- Grant note
- DOI: 10.13039/100009713, name: Foundation for Physical Therapy; DOI: 10.13039/100000002, name: National Institutes of Health, award: R01NS030853; DOI: 10.13039/100000005, name: U.S. Department of Defense, award: W81XWH-16-1-0503
- Language
- English
- Date published
- 09/01/2021
- Academic Unit
- Physical Therapy and Rehabilitation Science
- Record Identifier
- 9984294949902771
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