Journal article
A critical review on the potential impacts of neonicotinoid insecticide use: current knowledge of environmental fate, toxicity, and implications for human health
Environmental science--processes & impacts, Vol.22(6), pp.1315-1346
06/24/2020
DOI: 10.1039/C9EM00586B
PMID: 32267911
Abstract
Neonicotinoid insecticides are widely used in both urban and agricultural settings around the world. Historically, neonicotinoid insecticides have been viewed as ideal replacements for more toxic compounds, like organophosphates, due in part to their perceived limited potential to affect the environment and human health. This critical review investigates the environmental fate and toxicity of neonicotinoids and their metabolites and the potential risks associated with exposure. Neonicotinoids are found to be ubiquitous in the environment, drinking water, and food, with low-level exposure commonly documented below acceptable daily intake standards. Available toxicological data from animal studies indicate possible genotoxicity, cytotoxicity, impaired immune function, and reduced growth and reproductive success at low concentrations, while limited data from ecological or cross-sectional epidemiological studies have identified acute and chronic health effects ranging from acute respiratory, cardiovascular, and neurological symptoms to oxidative genetic damage and birth defects. Due to the heavy use of neonicotinoids and potential for cumulative chronic exposure, these insecticides represent novel risks and necessitate further study to fully understand their risks to humans.
Details
- Title: Subtitle
- A critical review on the potential impacts of neonicotinoid insecticide use: current knowledge of environmental fate, toxicity, and implications for human health
- Creators
- Darrin A Thompson - University of Iowa, College of Public Health, Iowa City, USA, University of IowaHans-Joachim Lehmler - University of Iowa, College of Public Health, Iowa City, USADana W Kolpin - U.S. Geological Survey, Central Midwest Water Science Center, Iowa City, USAMichelle L Hladik - U.S. Geological Survey, California Water Science Center, Sacramento, USAJohn D Vargo - State Hygienic Laboratory at the University of Iowa, Iowa City, USAKeith E Schilling - Iowa Geological Survey, Iowa City, USAGregory H LeFevre - University of Iowa, Department of Civil & Environmental Engineering, Iowa City, USATonya L Peeples - Department of Chemical Engineering, University Park, USAMatthew C Poch - University of Iowa, College of Public Health, Iowa City, USALauren E LaDuca - University of Iowa, College of Public Health, Iowa City, USADavid M Cwiertny - University of Iowa, Center for Health Effects of Environmental Contamination, Iowa City, USA, University of IowaR. William Field - University of Iowa, College of Public Health, Iowa City, USA
- Resource Type
- Journal article
- Publication Details
- Environmental science--processes & impacts, Vol.22(6), pp.1315-1346
- DOI
- 10.1039/C9EM00586B
- PMID
- 32267911
- NLM abbreviation
- Environ Sci Process Impacts
- ISSN
- 2050-7887
- eISSN
- 2050-7895
- Grant note
- DOI: 10.13039/100006803, name: Heartland Center for Occupational Safety and Health, award: T42OH008491; DOI: 10.13039/100008893, name: University of Iowa; DOI: 10.13039/100000001, name: National Science Foundation, award: 1803197
- Language
- English
- Date published
- 06/24/2020
- Academic Unit
- Center for Health Effects of Environmental Contamination; Civil and Environmental Engineering; Occupational and Environmental Health; Epidemiology; Earth and Environmental Sciences; Iowa Neuroscience Institute; IIHR--Hydroscience and Engineering; Public Policy Center (Archive); Chemical and Biochemical Engineering
- Record Identifier
- 9983992002602771
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