Journal article
A cubic B-spline-based hybrid registration of lung CT images for a dynamic airway geometric model with large deformation
Physics in medicine & biology, Vol.56(1), pp.203-218
01/07/2011
DOI: 10.1088/0031-9155/56/1/013
PMCID: PMC3115562
PMID: 21149947
Abstract
The goal of this study is to develop a matching algorithm that can handle large geometric changes in x-ray computed tomography (CT)-derived lung geometry occurring during deep breath maneuvers. These geometric relationships are further utilized to build a dynamic lung airway model for computational fluid dynamics (CFD) studies of pulmonary air flow. The proposed algorithm is based on a cubic B-spline-based hybrid registration framework that incorporates anatomic landmark information with intensity patterns. A sequence of invertible B-splines is composed in a multiresolution framework to ensure local invertibility of the large deformation transformation and a physiologically meaningful similarity measure is adopted to compensate for changes in voxel intensity due to inflation. Registrations are performed using the proposed approach to match six pairs of 3D CT human lung datasets. Results show that the proposed approach has the ability to match the intensity pattern and the anatomical landmarks, and ensure local invertibility for large deformation transformations. Statistical results also show that the proposed hybrid approach yields significantly improved results as compared with approaches using either landmarks or intensity alone.
Details
- Title: Subtitle
- A cubic B-spline-based hybrid registration of lung CT images for a dynamic airway geometric model with large deformation
- Creators
- Youbing Yin - University of IowaEric A Hoffman - University of IowaKai Ding - University of IowaJoseph M Reinhardt - University of IowaChing-Long Lin - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Physics in medicine & biology, Vol.56(1), pp.203-218
- DOI
- 10.1088/0031-9155/56/1/013
- PMID
- 21149947
- PMCID
- PMC3115562
- NLM abbreviation
- Phys Med Biol
- ISSN
- 0031-9155
- eISSN
- 1361-6560
- Grant note
- UL1 RR024979-05 || RR / National Center for Research Resources : NCRR R01 HL094315-05 || HL / National Heart, Lung, and Blood Institute : NHLBI R01 HL064368-10 || HL / National Heart, Lung, and Blood Institute : NHLBI S10 RR022421-01A2 || RR / National Center for Research Resources : NCRR R01 HL079406-05 || HL / National Heart, Lung, and Blood Institute : NHLBI R01 EB005823-03 || EB / National Institute of Biomedical Imaging and Bioengineering : NIBIB
- Language
- English
- Date published
- 01/07/2011
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Mechanical Engineering; Internal Medicine
- Record Identifier
- 9984196556502771
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