A data resource from concurrent intracranial stimulation and functional MRI of the human brain

W H Thompson; R Nair; H Oya; O Esteban; J M Shine; C I Petkov; R A Poldrack; M Howard; R Adolphs

doi:10.1038/s41597-020-00595-y

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A data resource from concurrent intracranial stimulation and functional MRI of the human brain

Journal article

Open access

Peer reviewed

A data resource from concurrent intracranial stimulation and functional MRI of the human brain

W H Thompson, R Nair, H Oya, O Esteban, J M Shine, C I Petkov, R A Poldrack, M Howard and R Adolphs

Scientific data, Vol.7(1), pp.258-258

08/05/2020

DOI: 10.1038/s41597-020-00595-y

PMCID: PMC7406507

PMID: 32759965

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Abstract

Mapping the causal effects of one brain region on another is a challenging problem in neuroscience that we approached through invasive direct manipulation of brain function together with concurrent whole-brain measurement of the effects produced. Here we establish a unique resource and present data from 26 human patients who underwent electrical stimulation during functional magnetic resonance imaging (es-fMRI). The patients had medically refractory epilepsy requiring surgically implanted intracranial electrodes in cortical and subcortical locations. One or multiple contacts on these electrodes were stimulated while simultaneously recording BOLD-fMRI activity in a block design. Multiple runs exist for patients with different stimulation sites. We describe the resource, data collection process, preprocessing using the fMRIPrep analysis pipeline and management of artifacts, and provide end-user analyses to visualize distal brain activation produced by site-specific electrical stimulation. The data are organized according to the brain imaging data structure (BIDS) specification, and are available for analysis or future dataset contributions on openneuro.org including both raw and preprocessed data.

Magnetic Resonance Imaging

Brain - diagnostic imaging

Electric Stimulation

Humans

Brain Mapping

Drug Resistant Epilepsy - diagnostic imaging

Electrodes, Implanted

Details

Title: Subtitle: A data resource from concurrent intracranial stimulation and functional MRI of the human brain
Creators: W H Thompson - Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
R Nair - Division of Humanities and Social Sciences, California Institute of Technology, Pasadena, CA, USA
H Oya - Iowa Neuroscience Institute, University of Iowa, Iowa City, IA, USA
O Esteban - Department of Psychology, Stanford University, Stanford, USA
J M Shine - Brain and Mind Centre, The University of Sydney, Sydney, NSW, Australia
C I Petkov - Newcastle University Medical School, Newcastle Upon Tyne, UK
R A Poldrack - Department of Psychology, Stanford University, Stanford, USA
M Howard - Iowa Neuroscience Institute, University of Iowa, Iowa City, IA, USA
R Adolphs - Division of Humanities and Social Sciences, California Institute of Technology, Pasadena, CA, USA. Radolphs@caltech.edu
Resource Type: Journal article
Publication Details: Scientific data, Vol.7(1), pp.258-258
DOI: 10.1038/s41597-020-00595-y
PMID: 32759965
PMCID: PMC7406507
NLM abbreviation: Sci Data
ISSN: 2052-4463
eISSN: 2052-4463
Publisher: England
Grant note: 102961/Z/13/Z / Wellcome Trust R24 MH117179 / NIMH NIH HHS U01 NS103780 / NINDS NIH HHS
Language: English
Date published: 08/05/2020
Academic Unit: Neurology; Iowa Neuroscience Institute; Neurosurgery; Otolaryngology
Record Identifier: 9984070787202771

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