A deficiency in S-adenosylmethionine synthetase interrupts assembly of the septal ring in Escherichia coli K-12

S J Ryan Arends; David S Weiss; Shan Wang; Elaine B Newman

doi:10.1111/j.1365-2958.2005.04864.x

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A deficiency in S-adenosylmethionine synthetase interrupts assembly of the septal ring in Escherichia coli K-12

Journal article

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A deficiency in S-adenosylmethionine synthetase interrupts assembly of the septal ring in Escherichia coli K-12

S J Ryan Arends, David S Weiss, Shan Wang and Elaine B Newman

Molecular microbiology, Vol.58(3), pp.791-799

11/2005

DOI: 10.1111/j.1365-2958.2005.04864.x

PMID: 16238627

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Abstract

A mutant in which S-adenosylmethionine synthetase is underexpressed makes filaments with no visible septa. Examination with GFP fusions to various septal proteins shows that FtsZ, ZipA and FtsA localize to the septal ring, but FtsQ, FtsW, FtsI or FtsN do not. The requirement for S-adenosylmethionine suggests that some methylation reaction is required before a complete septal ring can be assembled.

Membrane Proteins - genetics

Cell Cycle Proteins - metabolism

Escherichia coli Proteins - metabolism

Methionine Adenosyltransferase - metabolism

Escherichia coli K12 - cytology

Aztreonam - pharmacology

Recombinant Fusion Proteins - metabolism

Cell Division - physiology

Methionine Adenosyltransferase - genetics

Escherichia coli K12 - metabolism

Escherichia coli K12 - drug effects

Cell Cycle Proteins - genetics

Cytoskeleton - metabolism

Escherichia coli Proteins - genetics

Recombinant Fusion Proteins - genetics

Anti-Bacterial Agents - pharmacology

Membrane Proteins - metabolism

Escherichia coli K12 - genetics

Methylation

S-Adenosylmethionine - metabolism

Details

Title: Subtitle: A deficiency in S-adenosylmethionine synthetase interrupts assembly of the septal ring in Escherichia coli K-12
Creators: S J Ryan Arends
David S Weiss
Shan Wang - Biology Department, Concordia University, 1455 de Maisonneuve Ave., Montreal, Quebec H3G 1M8, Canada
Elaine B Newman
Resource Type: Journal article
Publication Details: Molecular microbiology, Vol.58(3), pp.791-799
Publisher: England
DOI: 10.1111/j.1365-2958.2005.04864.x
PMID: 16238627
ISSN: 0950-382X
eISSN: 1365-2958
Grant note: T32 G08365-13 / PHS HHS
Language: English
Date published: 11/2005
Academic Unit: Microbiology and Immunology
Record Identifier: 9984001211702771

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