Journal article
A deficiency in the B cell response of C57BL/6 mice correlates with loss of macrophage-mediated killing of Leishmania amazonensis
International journal for parasitology, Vol.40(2), pp.157-161
02/2010
DOI: 10.1016/j.ijpara.2009.11.010
PMCID: PMC2814795
PMID: 20004204
Abstract
Infection of C3HeB/FeJ and C57BL/6 mice with Leishmania major stimulates a healing cell-mediated immune response, while Leishmania amazonensis infection leads to chronic disease. Here we show C3HeB/FeJ mice co-infected with both species of Leishmania heal, while co-infected C57BL/6 mice do not. Using an in vitro killing assay we determined B cells from infected C57BL/6 mice are ineffective in promoting parasite killing compared with B cells from infected C3HeB/FeJ mice. Furthermore, infected C57BL/6 mice produce less antigen-specific antibodies compared with infected C3HeB/FeJ mice. These findings suggest B cells play a required role in the cell-mediated immune response against L. amazonensis.
Details
- Title: Subtitle
- A deficiency in the B cell response of C57BL/6 mice correlates with loss of macrophage-mediated killing of Leishmania amazonensis
- Creators
- Katherine N Gibson-CorleyPaola M BoggiattoRami M MukbelChristine A PetersenDouglas E Jones
- Resource Type
- Journal article
- Publication Details
- International journal for parasitology, Vol.40(2), pp.157-161
- DOI
- 10.1016/j.ijpara.2009.11.010
- PMID
- 20004204
- PMCID
- PMC2814795
- NLM abbreviation
- Int J Parasitol
- ISSN
- 0020-7519
- eISSN
- 1879-0135
- Publisher
- Elsevier Ltd
- Grant note
- DOI: 10.13039/100000002, name: National Institutes of Health, award: K08AI076616, AI48357
- Language
- English
- Date published
- 02/2010
- Academic Unit
- Epidemiology; Pathology; Internal Medicine; Ophthalmology and Visual Sciences
- Record Identifier
- 9983995020002771
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