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A delicate initiation: Lipolysis of lipid droplets fuels glioblastoma
Journal article   Open access   Peer reviewed

A delicate initiation: Lipolysis of lipid droplets fuels glioblastoma

Kailin Yang and Jeremy N. Rich
Molecular cell, Vol.81(13), pp.2686-2687
07/01/2021
DOI: 10.1016/j.molcel.2021.06.013
PMID: 34214442
url
https://doi.org/10.1016/j.molcel.2021.06.013View
Published (Version of record) Open Access

Abstract

Liu et al. (2021) demonstrate that CHK alpha 2 is capable of promoting lipolysis of lipid droplets through mechanisms that require sequential steps of post-translational modifications after glucose deprivation. Intriguingly, the oxidation of fatty acids derived from lipid droplets is essential for the survival of tumor cells that informs clinical outcome among glioblastoma patients.
Biochemistry & Molecular Biology Cell Biology Life Sciences & Biomedicine Science & Technology

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