Journal article
A detailed multipoint map of human chromosome 4 provides evidence for linkage heterogeneity and position-specific recombination rates
American journal of human genetics, Vol.48(5), pp.911-925
05/01/1991
PMCID: PMC1683054
PMID: 1673289
Abstract
Utilizing the CEPH reference panel and genotypic data for 53 markers, we have constructed a 20-locus multipoint genetic map of human chromosome 4. New RFLPs are reported for four loci. The map integrates a high-resolution genetic map of 4p16 into a continuous map extending to 4q31 and an unlinked cluster of three loci at 4q35. The 20 linked markers form a continuous linkage group of 152 cM in males and 202 cM in females. Likely genetic locations are provided for 25 polymorphic anonymous sequences and 28 gene-specific RFLPs. The map was constructed employing the LINKAGE and CRIMAP computational methodologies to build the multipoint map via a stepwise algorithm. A detailed 10-point map of the 4p16 region constructed from the CEPH panel provides evidence for heterogeneity in the linkage maps constructed from families segregating for Huntington disease (HD). It additionally provides evidence for position-specific recombination frequencies in the telomeric region of 4p.
Details
- Title: Subtitle
- A detailed multipoint map of human chromosome 4 provides evidence for linkage heterogeneity and position-specific recombination rates
- Creators
- Kenneth H. Buetow - Fox Chase Cancer CenterRita Shiang - University of IowaPing Yang - Fox Chase Cancer CenterYusuke Nakamura - University of UtahG. Mark Lathrop - University of UtahRaymond White - University of UtahJohn J. Wasmuth - Department of Biological Chemistry, University of California, United StatesStephen Wood - University of British ColumbiaLaura D. Berdahl - Department of Pediatrics, University of Iowa, United StatesNancy J. Leysens - Department of Pediatrics, University of Iowa, United StatesTimothy M. Ritty - Department of Pediatrics, University of Iowa, United StatesMolly E. Wise - Department of Pediatrics, University of Iowa, United StatesJeffrey C. Murray - Department of Pediatrics, University of Iowa, United States
- Resource Type
- Journal article
- Publication Details
- American journal of human genetics, Vol.48(5), pp.911-925
- PMID
- 1673289
- PMCID
- PMC1683054
- NLM abbreviation
- Am J Hum Genet
- ISSN
- 0002-9297
- eISSN
- 1537-6605
- Number of pages
- 15
- Grant note
- S07RR005895 / National Center for Research Resources (http://data.elsevier.com/vocabulary/SciValFunders/100000097)
- Language
- English
- Date published
- 05/01/1991
- Academic Unit
- Anatomy and Cell Biology; Stead Family Department of Pediatrics; Epidemiology; Pediatric Dentistry; Craniofacial Anomalies Research Center; Dental Research
- Record Identifier
- 9985035880702771
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