Journal article
A direct physical association between ETS and AP-1 transcription factors in normal human T cells
Immunity (Cambridge, Mass.), Vol.3(2), pp.223-237
1995
DOI: 10.1016/1074-7613(95)90092-6
PMID: 7648395
Abstract
The Ets and AP-1 families of transcription factors bind distinct DNA elements and subserve diverse functions in multiple lymphoid and nonlymphoid cell types. Functionally important Ets and AP-1 binding sites have been identified in a large number of enhancer elements, suggesting Important cooperative interactions between these two families of transcription factors. In this report, we have demonstrated a direct physical interaction between Ets and AP-1 proteins both in vitro and in activated human T cells. This interaction is mediated by the binding of the basic domain of Jun to the Ets domain of Eta proteins. Jun, in association with Ets, is capable of interacting with Fos family members to form a trimolecular protein complex. The physical association between Ets-1 and AP-1 proteins is required for the transcriptional activity of enhancer elements containing adjacent Eta and AP-1 binding sites. We conclude that direct physical interactions between Ets and AP-1 transcription factors play an important role in regulating mammalian gene expression.
Details
- Title: Subtitle
- A direct physical association between ETS and AP-1 transcription factors in normal human T cells
- Creators
- Alexander G BassukJeffrey M Leiden
- Resource Type
- Journal article
- Publication Details
- Immunity (Cambridge, Mass.), Vol.3(2), pp.223-237
- Publisher
- Elsevier Inc
- DOI
- 10.1016/1074-7613(95)90092-6
- PMID
- 7648395
- ISSN
- 1074-7613
- eISSN
- 1097-4180
- Language
- English
- Date published
- 1995
- Academic Unit
- Neurology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Neurology (Pediatrics)
- Record Identifier
- 9984020716302771
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