A dose escalation study of ORG 10172 (low molecular weight heparinoid) in stroke

J BILLER; E. W MASSEY; C. T KISKER; G. J TOFFOL; C. S GREENBERG; K. J BANWART; C BERTELS; D. W BECK; M WALKER; H. N MAGNANI; J. R MARLER; H P Adams Jr; J. N DAVIS; A BRUNO; R. A HENRIKSEN; R. J LINHARDT; L. B GOLDSTEIN; M ALBERTS

doi:10.1212/WNL.39.2.262

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A dose escalation study of ORG 10172 (low molecular weight heparinoid) in stroke

Journal article

Peer reviewed

A dose escalation study of ORG 10172 (low molecular weight heparinoid) in stroke

J BILLER, E. W MASSEY, C. T KISKER, G. J TOFFOL, C. S GREENBERG, K. J BANWART, C BERTELS, D. W BECK, M WALKER, H. N MAGNANI, …

Neurology, Vol.39(2), pp.262-265

1989

DOI: 10.1212/WNL.39.2.262

PMID: 2464774

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Abstract

An intravenous infusion of a low molecular weight heparinoid, with a reduced risk of hemorrhage, may be an alternative to heparin in the management of acute ischemic stroke. To evaluate this hypothesis, we studied the safety of the heparinoid, ORG 10172, in a dose-escalation study in 26 patients. The drug was administered as a loading bolus followed by a 7-day infusion in five rates with target anti-factor Xa levels from 0.2 to 1.0 U/ml. The drug was well tolerated; no major bleeding complications or thrombocytopenia occurred. There were no deaths or hemorrhagic transformation of cerebral infarctions. The results indicate that ORG 10172 at doses to achieve a level of 1.0 U/ml or less may be used safely in management of acute cerebral infarction.

Biological and medical sciences

Medical sciences

Blood. Blood coagulation. Reticuloendothelial system

Pharmacology. Drug treatments

Details

Title: Subtitle: A dose escalation study of ORG 10172 (low molecular weight heparinoid) in stroke
Creators: J BILLER - Univ. Iowa, dep. neurology, Iowa City IA 52242, United States
E. W MASSEY - Univ. Iowa, dep. neurology, Iowa City IA 52242, United States
C. T KISKER - Univ. Iowa, dep. neurology, Iowa City IA 52242, United States
G. J TOFFOL - Univ. Iowa, dep. neurology, Iowa City IA 52242, United States
C. S GREENBERG - Univ. Iowa, dep. neurology, Iowa City IA 52242, United States
K. J BANWART - Univ. Iowa, dep. neurology, Iowa City IA 52242, United States
C BERTELS - Univ. Iowa, dep. neurology, Iowa City IA 52242, United States
D. W BECK - Univ. Iowa, dep. neurology, Iowa City IA 52242, United States
M WALKER - Univ. Iowa, dep. neurology, Iowa City IA 52242, United States
H. N MAGNANI - Univ. Iowa, dep. neurology, Iowa City IA 52242, United States
J. R MARLER - Univ. Iowa, dep. neurology, Iowa City IA 52242, United States
H P Adams Jr - Univ. Iowa, dep. neurology, Iowa City IA 52242, United States
J. N DAVIS - Duke University
A BRUNO - Univ. Iowa, dep. neurology, Iowa City IA 52242, United States
R. A HENRIKSEN - Univ. Iowa, dep. neurology, Iowa City IA 52242, United States
R. J LINHARDT - Univ. Iowa, dep. neurology, Iowa City IA 52242, United States
L. B GOLDSTEIN - Univ. Iowa, dep. neurology, Iowa City IA 52242, United States
M ALBERTS - Univ. Iowa, dep. neurology, Iowa City IA 52242, United States
Resource Type: Journal article
Publication Details: Neurology, Vol.39(2), pp.262-265
Publisher: Lippincott Williams & Wilkins; Hagerstown, MD
DOI: 10.1212/WNL.39.2.262
PMID: 2464774
ISSN: 0028-3878
eISSN: 1526-632X
Language: English
Date published: 1989
Academic Unit: Neurology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute
Record Identifier: 9984020633602771

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