A dose-escalation study of large doses of naloxone for treatment of patients with acute cerebral ischemia

Harold P Adams Jr; Charles P Olinger; William G Barsan; Michael J Butler; Neill R Graff-Radford; Thomas G Brott; Jose Biller; Hanna Damasio; Thomas  TOMSICK; Mark Goldberg; Judith A Spilker; E BERLINGER; J DAMBROSIA; Michelle Biros; R HOLLERN

doi:10.1161/01.STR.17.3.404

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A dose-escalation study of large doses of naloxone for treatment of patients with acute cerebral ischemia

Journal article

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A dose-escalation study of large doses of naloxone for treatment of patients with acute cerebral ischemia

Harold P Adams Jr, Charles P Olinger, William G Barsan, Michael J Butler, Neill R Graff-Radford, Thomas G Brott, Jose Biller, Hanna Damasio, Thomas TOMSICK, Mark Goldberg, …

Stroke (1970), Vol.17(3), pp.404-409

1986

DOI: 10.1161/01.STR.17.3.404

PMID: 3715936

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Abstract

A dose-escalation study was performed in 27 patients to determine the highest safe and potentially optimal dose of naloxone for treatment of acute cerebral ischemia. All patients received a bolus of naloxone followed by a continuous 24 hour infusion at an hourly rate 50% of the bolus. Loading doses ranged from 2.5 to 200 mg/m2. Total patient doses ranged from 52.3 to 4978 mg. No major dose-related side effects occurred. This study was not designed to determine naloxone's efficacy in stroke, but transient or sustained improvement was observed in 13 patients. Three patients' neurological condition worsened within three hours after the naloxone was discontinued. Our experience suggests that further therapeutic trials of naloxone are worthwhile

Cardiovascular System

Biological and medical sciences

Miscellaneous

Medical sciences

Pharmacology. Drug treatments

Details

Title: Subtitle: A dose-escalation study of large doses of naloxone for treatment of patients with acute cerebral ischemia
Creators: Harold P Adams Jr - Univ. Iowa, dep. neurology, Iowa City IA 52242, United States
Charles P Olinger - Univ. Iowa, dep. neurology, Iowa City IA 52242, United States
William G Barsan - Univ. Iowa, dep. neurology, Iowa City IA 52242, United States
Michael J Butler - Univ. Iowa, dep. neurology, Iowa City IA 52242, United States
Neill R Graff-Radford - Univ. Iowa, dep. neurology, Iowa City IA 52242, United States
Thomas G Brott - Univ. Iowa, dep. neurology, Iowa City IA 52242, United States
Jose Biller - Univ. Iowa, dep. neurology, Iowa City IA 52242, United States
Hanna Damasio - Univ. Iowa, dep. neurology, Iowa City IA 52242, United States
Thomas TOMSICK - Univ. Iowa, dep. neurology, Iowa City IA 52242, United States
Mark Goldberg - Univ. Iowa, dep. neurology, Iowa City IA 52242, United States
Judith A Spilker - Univ. Iowa, dep. neurology, Iowa City IA 52242, United States
E BERLINGER - Univ. Iowa, dep. neurology, Iowa City IA 52242, United States
J DAMBROSIA - Univ. Iowa, dep. neurology, Iowa City IA 52242, United States
Michelle Biros - Univ. Iowa, dep. neurology, Iowa City IA 52242, United States
R HOLLERN - Univ. Iowa, dep. neurology, Iowa City IA 52242, United States
Resource Type: Journal article
Publication Details: Stroke (1970), Vol.17(3), pp.404-409
DOI: 10.1161/01.STR.17.3.404
PMID: 3715936
NLM abbreviation: Stroke
ISSN: 0039-2499
eISSN: 1524-4628
Publisher: Lippincott Williams & Wilkins; Hagerstown, MD
Language: English
Date published: 1986
Academic Unit: Neurology; Iowa Neuroscience Institute
Record Identifier: 9984020781902771

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