Journal article
The impact of septicemia occurring during hospitalization for renal transplantation procedures on outcomes in adults in United States
PLoS One, Vol.12(6), p.0179466
06/13/2017
DOI: 10.1371/journal.pone.0179466
PMCID: PMC5469480
PMID: 28609479
Abstract
INTRODUCTION: Immediate success rates of renal transplantation (RT) procedures are generally very high. National estimates of the impact of post-operative complications, specifically, septicemia occurring during hospitalization for RT's on outcomes is unclear. We sought, to examine the prevalence of septicemia in patients having renal transplantation procedures and to quantify the impact of septicemia on in-hospital mortality (IHM), length of stay (LOS), and hospital charges (HC).
MATERIALS AND METHODS: We performed a retrospective analysis of the Nationwide Inpatient Sample (NIS) for the years 2004 to 2010. All patients aged ≥18 years who underwent RT were selected. Association between occurrence of septicemia and outcomes (IHM, HC and LOS) was examined by multivariable linear and logistic regression models with adjustments for patient and hospital level confounders.
RESULTS: During the study period, 113,058 patients underwent RT, and, of these, 2459 (2.2%) developed septicemia. Characteristics included mean age (50 years), gender (males, 60%) and race (whites, 54%). Majority of RT's were performed in teaching (96%) and large institutes (85.5%). Outcomes for patients with septicemia and without septicemia, included: IHM (12.9% vs. 0.4%), discharge routinely (42.4% vs. 82.6%), mean HC ($528,980 vs. $182,165), mean LOS in days (35.2 vs 7.3), respectively, Those who developed septicemia were associated with significantly higher HC (estimate: 0.8357, 95% CI: {0.7636-0.9077}, increase of $ 247,081 from mean, p
CONCLUSIONS: Despite advances in medical/surgical care, septicemia is not an uncommon complication in patients having renal transplantation procedures and is associated with poor outcomes. Increasing age and co-morbid burden are independent predictors of occurrence of septicemia.
Details
- Title: Subtitle
- The impact of septicemia occurring during hospitalization for renal transplantation procedures on outcomes in adults in United States
- Creators
- Veerajalandhar Allareddy - University of IowaSankeerth Rampa - University of NebraskaAlexandre T Rotta - Case Western Reserve UniversityVeerasathpurush Allareddy - University of Iowa
- Resource Type
- Journal article
- Publication Details
- PLoS One, Vol.12(6), p.0179466
- DOI
- 10.1371/journal.pone.0179466
- PMID
- 28609479
- PMCID
- PMC5469480
- ISSN
- 1932-6203
- eISSN
- 1932-6203
- Number of pages
- 15
- Copyright
- Copyright: © 2017 Allareddy et al.
- Comment
- Data Availability From Agency of Health Care Research and Quality. We used the NIS database that can be purchased from HCUP-AHRQ after completing a data user agreement. We are unable to deposit the actual data in a public repository as this would violate the data user agreement with HCUP-AHRQ. The data is available from the Online HCUP Central Distributor. Phone: 866-556-HCUP (4287) Email: vog.qrha@rotubirtsiDPUCHhttps://www.hcup-us.ahrq.gov/tech_assist/centdist.jsp.
- Language
- English
- Date published
- 06/13/2017
- Academic Unit
- Stead Family Department of Pediatrics; Carver College of Medicine; College of Dentistry
- Record Identifier
- 9983557342002771
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