Journal article
A field-focusing device to increase power output of ThermoRod implants for thermal ablation of tissue
Journal of biomedical materials research, Vol.63(5), pp.650-656
2002
DOI: 10.1002/jbm.10385
PMID: 12209912
Abstract
Induction heating of small, cylindrical ferromagnetic implants (1.4 cm long and 1 mm in diameter) is a method for treating deep-seated tumors. These implants, or ThermoRods trade mark, are placed within a lesion in 1-cm(2) arrays and are exposed to an alternating magnetic field. The implants absorb energy from that field and transfer it as heat to the surrounding tissue. Each ThermoRod trade mark offers approximately 400 mW of power, and to kill cells, the target temperature must be greater than 42 degrees C. In this work, a magnetic field-focusing device is employed to concentrate the induced magnetic flux toward a local region near the base of the prostate to increase the power output of proximal ThermoRods trade mark. This, in turn, allows for more complete thermal ablation of lesions near the base of the prostate where the heat-sink characteristics of the bladder can cause significant power losses. Boundary element analysis and in vitro testing have shown that the use of a ferrofluid-based field-focusing device can lead to a significant increase in power output of approximately 25% and 13%, respectively, of proximal ThermoRods trade mark. These preliminary results indicate that the incorporation of such a ferrofluid-based focusing device into ThermoRod trade mark treatments is promising for the avoidance of significant power loss and for assuring complete thermal ablation of prostatic lesions.
Details
- Title: Subtitle
- A field-focusing device to increase power output of ThermoRod implants for thermal ablation of tissue
- Creators
- Andrew H BERTHUSEN - Department of Biomedical Engineering, University of Iowa, Iowa City, Iowa 52242, United StatesRobert D TUCKER - Department of Pathology, University of Iowa, Iowa City, Iowa 52242, United StatesJoon B PARK - Department of Biomedical Engineering, University of Iowa, Iowa City, Iowa 52242, United States
- Resource Type
- Journal article
- Publication Details
- Journal of biomedical materials research, Vol.63(5), pp.650-656
- Publisher
- John Wiley & Sons; New York, NY
- DOI
- 10.1002/jbm.10385
- PMID
- 12209912
- ISSN
- 0021-9304
- eISSN
- 1097-4636
- Language
- English
- Date published
- 2002
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Pathology
- Record Identifier
- 9984047997802771
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