Journal article
A functional polymorphism of the mu -opioid receptor gene is associated with completed suicides
Journal of Neural Transmission, Vol.115(3), pp.531-536
03/01/2008
DOI: 10.1007/s00702-007-0853-y
PMID: 18250953
Abstract
A recent linkage study suggested that a putative locus for suicidal behavior independent of psychiatric disease phenotypes lies at 5' upstream of the mu -opioid receptor (OPRM1) gene. We explored an association between suicide and genetic variations of the OPRM1 using a case-control study of 183 completed suicides and 374 control subjects. We genotyped four single nucleotide polymorphisms (SNPs) including a common A118G SNP. The genotypic and allelic distributions of the A118G SNP were significantly different between the completed suicide and control groups (P = 0.014 and 0.039, respectively). A dominant model analysis of the A118G SNP showed an enhanced association with suicide (P = 0.0041, Odds ratio 0.575) and this significant association was observed with a logistic regression analysis that takes sex and age factors into account (P = 0.021). Our results raise the possibility that the A118G SNP of the OPRM1 gene is associated with suicide.
Details
- Title: Subtitle
- A functional polymorphism of the mu -opioid receptor gene is associated with completed suicides
- Creators
- A HishimotoH CuiK MouriH NushidaY UenoK MaedaO Shirakawa
- Resource Type
- Journal article
- Publication Details
- Journal of Neural Transmission, Vol.115(3), pp.531-536
- DOI
- 10.1007/s00702-007-0853-y
- PMID
- 18250953
- ISSN
- 0300-9564
- eISSN
- 1435-1463
- Language
- English
- Date published
- 03/01/2008
- Academic Unit
- Iowa Neuroscience Institute; Fraternal Order of Eagles Diabetes Research Center; Neuroscience and Pharmacology
- Record Identifier
- 9984040361902771
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