Journal article
A gene for autosomal dominant nonsyndromic hearing loss (DFNA12) maps to chromosome 11q22-24
American journal of human genetics, Vol.60(5), pp.1168-1173
05/1997
PMCID: PMC1712440
PMID: 9150164
Abstract
We performed linkage analysis in a Belgian family with autosomal dominant midfrequency hearing loss, which has a prelingual onset and a nonprogressive course in most patients. We found LOD scores >6 with markers on chromosome 11q. Analysis of key recombinants maps this deafness gene (DFNA12) to a 36-cM interval on chromosome 11q22-24, between markers D11S4120 and D11S912. The critical regions for the recessive deafness locus DFNB2 and the dominant locus DFNA11, which were previously localized to the long arm of chromosome 11, do not overlap with the candidate interval of DFNA12.
Details
- Title: Subtitle
- A gene for autosomal dominant nonsyndromic hearing loss (DFNA12) maps to chromosome 11q22-24
- Creators
- Kristien Verhoeven - Department of Medical Genetics, University of Antwerp, BelgiumGuy Van Camp - Department of Medical Genetics, University of Antwerp, BelgiumPaul J Govaerts - Department of Medical Genetics, University of Antwerp, BelgiumWendy Balemans - Department of Medical Genetics, University of Antwerp, BelgiumIsabelle Schatteman - Department of Medical Genetics, University of Antwerp, BelgiumMargriet Verstreken - Department of Medical Genetics, University of Antwerp, BelgiumLut Van Laer - Department of Medical Genetics, University of Antwerp, BelgiumRichard J H Smith - Department of Medical Genetics, University of Antwerp, BelgiumMatthew R Brown - Department of Medical Genetics, University of Antwerp, BelgiumPaul H Van de Heyning - Department of Medical Genetics, University of Antwerp, BelgiumThomas Somers - Department of Medical Genetics, University of Antwerp, BelgiumF Erwin Offeciers - Department of Medical Genetics, University of Antwerp, BelgiumPatrick J Willems - Department of Medical Genetics, University of Antwerp, Belgium
- Resource Type
- Journal article
- Publication Details
- American journal of human genetics, Vol.60(5), pp.1168-1173
- PMID
- 9150164
- PMCID
- PMC1712440
- NLM abbreviation
- Am J Hum Genet
- ISSN
- 0002-9297
- eISSN
- 1537-6605
- Language
- English
- Date published
- 05/1997
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Molecular Physiology and Biophysics; Anatomy and Cell Biology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Otolaryngology; Internal Medicine
- Record Identifier
- 9984007178302771
Metrics
29 Record Views