Journal article
A genetic study of platelet adenylate cyclase activity: evidence for a single major locus effect in fluoride-stimulated activity
American Journal of Human Genetics, Vol.49(2), pp.372-377
08/01/1991
PMCID: PMC1683318
PMID: 1867196
Abstract
The activity of membrane-bound platelet adenylate cyclase, when stimulated in vitro by several compounds (including fluoride), is significantly reduced in alcoholics compared with control subjects. We have begun a study of the genetics of this enzyme activity. Complex segregation analysis of basal (unstimulated) platelet adenylate cyclase activity in families reveals a mode of inheritance that cannot be accounted for by a simple mixed model of transmission. By contrast, adenylate cyclase activity stimulated by fluoride ion reveals a single major locus effect with a modest multifactorial background. These results suggest that a single factor in the second-messenger pathway may (a) account for the majority of individual differences in stimulation of adenylate cyclase of fluoride and (b) help explain the reduced activities previously observed in alcoholics.
Details
- Title: Subtitle
- A genetic study of platelet adenylate cyclase activity: evidence for a single major locus effect in fluoride-stimulated activity
- Creators
- Eric J. Devor - Washington University in St. LouisC Robert CloningerPaula L HoffmanBoris Tabakoff
- Resource Type
- Journal article
- Publication Details
- American Journal of Human Genetics, Vol.49(2), pp.372-377
- Publisher
- United States
- PMID
- 1867196
- PMCID
- PMC1683318
- ISSN
- 0002-9297
- eISSN
- 1537-6605
- Grant note
- AA-03539 / NIAAA NIH HHS MH-31302 / NIMH NIH HHS
- Language
- English
- Date published
- 08/01/1991
- Academic Unit
- Obstetrics and Gynecology
- Record Identifier
- 9983557419002771
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