Journal article
A genome-wide association study of DSM-IV cannabis dependence
Addiction biology, Vol.16(3), pp.514-518
07/2011
DOI: 10.1111/j.1369-1600.2010.00255.x
PMCID: PMC3117436
PMID: 21668797
Abstract
Despite twin studies showing that 50-70% of variation in DSM-IV cannabis dependence is attributable to heritable influences, little is known of specific genotypes that influence vulnerability to cannabis dependence. We conducted a genome-wide association study of DSM-IV cannabis dependence. Association analyses of 708 DSM-IV cannabis-dependent cases with 2346 cannabis-exposed non-dependent controls was conducted using logistic regression in PLINK. None of the 948 142 single nucleotide polymorphisms met genome-wide significance (P at E-8). The lowest P values were obtained for polymorphisms on chromosome 17 (rs1019238 and rs1431318, P values at E-7) in the ANKFN1 gene. While replication is required, this study represents an important first step toward clarifying the biological underpinnings of cannabis dependence.
Details
- Title: Subtitle
- A genome-wide association study of DSM-IV cannabis dependence
- Creators
- Arpana Agrawal - Department of Psychiatry, Washington University School of Medicine, 660 S. Euclid, Saint Louis, MO 63110, USA. arpana@wustl.eduMichael T LynskeyAnthony HinrichsRichard GruczaScott F SacconeRobert KruegerGene Environment Association Studies ConsortiumWilliam HowellsSherri FisherLouis FoxRobert CloningerDanielle M DickKimberly F DohenyHoward J EdenbergAlison M GoateVictor HesselbrockEric JohnsonJohn KramerSamuel KupermanJohn I Nurnberger JrElizabeth PughMarc SchuckitJay TischfieldJohn P RiceKathleen K BucholzLaura J BierutGENEVA Consortium
- Resource Type
- Journal article
- Publication Details
- Addiction biology, Vol.16(3), pp.514-518
- DOI
- 10.1111/j.1369-1600.2010.00255.x
- PMID
- 21668797
- PMCID
- PMC3117436
- NLM abbreviation
- Addict Biol
- ISSN
- 1355-6215
- eISSN
- 1369-1600
- Publisher
- United States
- Grant note
- R21DA026612 / NIDA NIH HHS R21 DA026612 / NIDA NIH HHS R01 AA01744 / NIAAA NIH HHS R01 DA018860 / NIDA NIH HHS R01 DA019963 / NIDA NIH HHS U01 HG004446-03 / NHGRI NIH HHS R01 DA013423 / NIDA NIH HHS DA18267 / NIDA NIH HHS DA23668 / NIDA NIH HHS HHSN268200782096C / NHLBI NIH HHS DA18860 / NIDA NIH HHS U10 AA008401-04 / NIAAA NIH HHS K02 AA018755 / NIAAA NIH HHS R01 DA013423-02 / NIDA NIH HHS U01 HG004438-01 / NHGRI NIH HHS R01 DA019963-03 / NIDA NIH HHS U10 AA008401-22 / NIAAA NIH HHS U01 HG004422 / NHGRI NIH HHS U01HG004438 / NHGRI NIH HHS U01 HG004446 / NHGRI NIH HHS U10 AA008401 / NIAAA NIH HHS U01 HG004438 / NHGRI NIH HHS R01 AA017444-03 / NIAAA NIH HHS R01 DA019963-02 / NIDA NIH HHS R01 DA018267 / NIDA NIH HHS R01 DA023668 / NIDA NIH HHS R01 DA018267-05 / NIDA NIH HHS U01 HG004438-03 / NHGRI NIH HHS P01 CA089392-05 / NCI NIH HHS R01 AA017444 / NIAAA NIH HHS R21 DA026612-02 / NIDA NIH HHS U01 HG004422-02 / NHGRI NIH HHS P01 CA089392 / NCI NIH HHS R01 DA018660-05 / NIDA NIH HHS R01 DA013423-05 / NIDA NIH HHS R01 DA023668-03 / NIDA NIH HHS P01 CA089392-10 / NCI NIH HHS
- Language
- English
- Date published
- 07/2011
- Academic Unit
- Psychiatry; Stead Family Department of Pediatrics
- Record Identifier
- 9984003467702771
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