Journal article
A genome-wide association study of alcohol dependence
Proceedings of the National Academy of Sciences - PNAS, Vol.107(11), pp.5082-5087
03/16/2010
DOI: 10.1073/pnas.0911109107
PMCID: PMC2841942
PMID: 20202923
Abstract
Excessive alcohol consumption is one of the leading causes of preventable death in the United States. Approximately 14% of those who use alcohol meet criteria during their lifetime for alcohol dependence, which is characterized by tolerance, withdrawal, inability to stop drinking, and continued drinking despite serious psychological or physiological problems. We explored genetic influences on alcohol dependence among 1,897 European-American and African-American subjects with alcohol dependence compared with 1,932 unrelated, alcohol-exposed, nondependent controls. Constitutional DNA of each subject was genotyped using the Illumina 1M beadchip. Fifteen SNPs yielded P < 10(-5), but in two independent replication series, no SNP passed a replication threshold of P < 0.05. Candidate gene GABRA2, which encodes the GABA receptor alpha 2 subunit, was evaluated independently. Five SNPs at GABRA2 yielded nominal (uncorrected) P < 0.05, with odds ratios between 1.11 and 1.16. Further dissection of the alcoholism phenotype, to disentangle the influence of comorbid substance-use disorders, will be a next step in identifying genetic variants associated with alcohol dependence.
Details
- Title: Subtitle
- A genome-wide association study of alcohol dependence
- Creators
- Laura J. Bierut - Washington University in St. LouisArpana Agrawal - Washington University in St. LouisKathleen K. Bucholz - Washington University in St. LouisKimberly F. Doheny - Johns Hopkins University School of MedicineCathy Laurie - University of WashingtonElizabeth Pugh - Johns Hopkins University School of MedicineSherri Fisher - Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USALouis Fox - Washington University in St. LouisWilliam Howells - Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USASarah Bertelsen - Icahn School of Medicine at Mount SinaiAnthony L. Hinrichs - Washington University in St. LouisLaura Almasy - Children's Hospital of PhiladelphiaNaomi Breslau - Michigan State UniversityRobert C. Culverhouse - Washington University in St. LouisDanielle M. Dick - Rutgers, The State University of New JerseyHoward J. Edenberg - Indiana University BloomingtonTatiana Foroud - University of IndianapolisRichard A. Grucza - Washington University in St. LouisDorothy Hatsukami - University of MinnesotaVictor Hesselbrock - University of ConnecticutEric O. Johnson - Research Triangle Park FoundationJohn Kramer - University of Iowa, PsychiatryRobert F. Krueger - University of MinnesotaSamuel Kuperman - University of Iowa, PsychiatryMichael Lynskey - Washington University in St. LouisKarl Mann - Heidelberg UniversityRosalind J. Neuman - Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USAMarkus M. Noethen - Life & Brain (Germany)John I. Nurnberger - Indiana UniversityBernice Porjesz - State University of New YorkMonika Ridinger - University of RegensburgNancy L. Saccone - Washington University in St. LouisScott F. Saccone - Washington University in St. LouisMarc A. Schuckit - University of California San DiegoJay A. Tischfield - Rutgers, The State University of New JerseyJen C. Wang - Washington University in St. LouisMarcella Rietschel - Heidelberg UniversityAlison M. Goate - Washington University in St. LouisJohn P. Rice - Washington University in St. LouisGene, Environment Association Studies (GENEVA) Consortium (Institution)
- Resource Type
- Journal article
- Publication Details
- Proceedings of the National Academy of Sciences - PNAS, Vol.107(11), pp.5082-5087
- DOI
- 10.1073/pnas.0911109107
- PMID
- 20202923
- PMCID
- PMC2841942
- NLM abbreviation
- Proc Natl Acad Sci U S A
- ISSN
- 0027-8424
- eISSN
- 1091-6490
- Publisher
- Natl Acad Sciences
- Number of pages
- 6
- Grant note
- National Institutes of Health (NIH) Genes; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA U10 AA008401 / COGA P01 CA089392 / COGEND National Institute on Alcohol Abuse and Alcoholism; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Alcohol Abuse & Alcoholism (NIAAA) National Genome Research Network (NGFNplus) U01 HG004446 / GENEVA Coordinating Center R01 DA013423 / FSCD U01 HG004422 / Environment and Health Initiative (GEI) National Institute on Drug Abuse; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Drug Abuse (NIDA) U01HG004438; HHSN268200782096C / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Language
- English
- Date published
- 03/16/2010
- Academic Unit
- Psychiatry; Stead Family Department of Pediatrics
- Record Identifier
- 9984003422202771
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