A genome-wide association study of marginal zone lymphoma shows association to the HLA region

Joseph Vijai; Brian K Link; Zhaoming Wang; George J Weiner; Sonja I Berndt; Yuanqing Ye; James R Cerhan; Christine F Skibola; Susan L Slager; Silvia de Sanjose; Mads Melbye; Bengt Glimelius; Paige M Bracci; Lucia Conde; Brenda M Birmann; Sophia S Wang; Angela R Brooks-Wilson; Carol Portlock; Qing Lan; Jacques Riby; Stephen M Ansell; Roel C H Vermeulen; Paul I W de Bakker; Kari E North; Jian Gu; Henrik Hjalgrim; Wendy Cozen; Nikolaus Becker; Lauren R Teras; John J Spinelli; Jenny Turner; Yawei Zhang; Mark P Purdue; Graham G Giles; Rachel S Kelly; Anne Zeleniuch-Jacquotte; Maria Grazia Ennas; Alain Monnereau; Kimberly A Bertrand; Demetrius Albanes; Tracy Lightfoot; Meredith Yeager; Charles C Chung; Laurie Burdett; Amy Hutchinson; Charles Lawrence; Rebecca Montalvan; Liming Liang; Jinyan Huang; Baoshan Ma; Danylo J Villano; Ann Maria; Marina Corines; Tinu Thomas; Anne J Novak; Ahmet Dogan; Mark Liebow; Carrie A Thompson; Thomas E Witzig; Thomas M Habermann; Martyn T Smith; Elizabeth A Holly; Rebecca D Jackson; Lesley F Tinker; Hans-Olov Adami; Karin E Smedby; Anneclaire J De Roos; Patricia Hartge; Lindsay M Morton; Richard K Severson; Yolanda Benavente; Paolo Boffetta; Paul Brennan; Lenka Foretova; Marc Maynadie; James McKay; Anthony Staines; W Ryan Diver; Claire M Vajdic; Bruce K Armstrong; Anne Kricker; Tongzhang Zheng; Theodore R Holford; Gianluca Severi; Paolo Vineis; Giovanni M Ferri; Rosalia Ricco; Lucia Miligi; Jacqueline Clavel; Edward Giovannucci; Peter Kraft; Jarmo Virtamo; Alex Smith; Eleanor Kane; Eve Roman; Brian C H Chiu; Joseph F Fraumeni; Xifeng Wu; Kenneth Offit; Stephen J Chanock; Nathaniel Rothman; Alexandra Nieters

doi:10.1038/ncomms6751

Back

A genome-wide association study of marginal zone lymphoma shows association to the HLA region

Journal article

Open access

Peer reviewed

A genome-wide association study of marginal zone lymphoma shows association to the HLA region

Joseph Vijai, Brian K Link, Zhaoming Wang, George J Weiner, Sonja I Berndt, Yuanqing Ye, James R Cerhan, Christine F Skibola, Susan L Slager, Silvia de Sanjose, …

Nature communications, Vol.6(1), pp.5751-5751

01/08/2015

DOI: 10.1038/ncomms6751

PMCID: PMC4287989

PMID: 25569183

Files and links (1)

url

https://doi.org/10.1038/ncomms6751View

Published (Version of record) Open Access

Abstract

Marginal zone lymphoma (MZL) is the third most common subtype of B-cell non-Hodgkin lymphoma. Here we perform a two-stage GWAS of 1,281 MZL cases and 7,127 controls of European ancestry and identify two independent loci near BTNL2 (rs9461741, P=3.95 × 10(-15)) and HLA-B (rs2922994, P=2.43 × 10(-9)) in the HLA region significantly associated with MZL risk. This is the first evidence that genetic variation in the major histocompatibility complex influences MZL susceptibility.

Computational Biology

European Continental Ancestry Group - genetics

Genome-Wide Association Study

Major Histocompatibility Complex - genetics

Humans

Polymorphism, Single Nucleotide - genetics

Butyrophilins

Genotype

Lymphoma, B-Cell, Marginal Zone - genetics

Membrane Glycoproteins - genetics

Details

Title: Subtitle: A genome-wide association study of marginal zone lymphoma shows association to the HLA region
Creators: Joseph Vijai - Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA
Brian K Link - Department of Internal Medicine, Carver College of Medicine, The University of Iowa, Iowa City, Iowa 52242, USA
Zhaoming Wang - Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Gaithersburg, Maryland 20877, USA
George J Weiner - Department of Internal Medicine, Carver College of Medicine, The University of Iowa, Iowa City, Iowa 52242, USA
Sonja I Berndt - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA
Yuanqing Ye - Department of Epidemiology, M.D. Anderson Cancer Center, Houston, Texas 77030, USA
James R Cerhan - Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA
Christine F Skibola - 1] Department of Epidemiology, School of Public Health and Comprehensive Cancer Center, Birmingham, Alabama 35233, USA Division of Environmental Health Sciences, University of California Berkeley School of Public Health, Berkeley, California 94720, USA
Susan L Slager - Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA
Silvia de Sanjose - 1] Unit of Infections and Cancer (UNIC), Cancer Epidemiology Research Programme, Institut Catala d'Oncologia, IDIBELL, Barcelona 8907, Spain Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Barcelona 8036, Spain
Mads Melbye - 1] Department of Epidemiology Research, Division of Health Surveillance and Research, Statens Serum Institut, Copenhagen 2300, Denmark Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA
Bengt Glimelius - 1] Department of Oncology and Pathology, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm 17176, Sweden Department of Radiology, Oncology and Radiation Science, Uppsala University, Uppsala 75105, Sweden
Paige M Bracci - Department of Epidemiology &Biostatistics, University of California San Francisco, San Francisco, California 94118, USA
Lucia Conde - 1] Department of Epidemiology, School of Public Health and Comprehensive Cancer Center, Birmingham, Alabama 35233, USA Division of Environmental Health Sciences, University of California Berkeley School of Public Health, Berkeley, California 94720, USA
Brenda M Birmann - Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Sophia S Wang - Department of Cancer Etiology, City of Hope Beckman Research Institute, Duarte, California 91030, USA
Angela R Brooks-Wilson - 1] Genome Sciences Centre, BC Cancer Agency, Vancouver, British Columbia, Canada V5Z1L3 Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, British Columbia, Canada V5A1S6
Carol Portlock - Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA
Qing Lan - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA
Jacques Riby - 1] Department of Epidemiology, School of Public Health and Comprehensive Cancer Center, Birmingham, Alabama 35233, USA Division of Environmental Health Sciences, University of California Berkeley School of Public Health, Berkeley, California 94720, USA
Stephen M Ansell - Department of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
Roel C H Vermeulen - 1] Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht 3584 CX, The Netherlands Institute for Risk Assessment Sciences, Utrecht University, Utrecht 3508 TD, The Netherlands
Paul I W de Bakker - 1] Department of Medical Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht 3584 CG, The Netherlands Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht 3584 CX, The Netherlands
Kari E North - 1] Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA Carolina Center for Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
Jian Gu - Department of Epidemiology, M.D. Anderson Cancer Center, Houston, Texas 77030, USA
Henrik Hjalgrim - Department of Epidemiology Research, Division of Health Surveillance and Research, Statens Serum Institut, Copenhagen 2300, Denmark
Wendy Cozen - 1] Department of Preventive Medicine, USC Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA Norris Comprehensive Cancer Center, USC Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
Nikolaus Becker - Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany
Lauren R Teras - Epidemiology Research Program, American Cancer Society, Atlanta, Georgia 30303, USA
John J Spinelli - 1] Cancer Control Research, BC Cancer Agency, Vancouver, British Columbia, Canada V5Z1L3 School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada V6T1Z3
Jenny Turner - 1] Pathology, Australian School of Advanced Medicine, Macquarie University, Sydney, New South Wales 2109, Australia Department of Histopathology, Douglass Hanly Moir Pathology, Macquarie Park, New South Wales 2113, Australia
Yawei Zhang - Department of Environmental Health Sciences, Yale School of Public Health, New Haven, Connecticut 06520, USA
Mark P Purdue - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA
Graham G Giles - 1] Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria 3053, Australia Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Carlton, Victoria 3010, Australia
Rachel S Kelly - MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London W2 1PG, UK
Anne Zeleniuch-Jacquotte - 1] Department of Population Health, New York University School of Medicine, New York, New York 10016, USA Cancer Institute, New York University School of Medicine, New York, New York 10016, USA
Maria Grazia Ennas - Department of Biomedical Science, University of Cagliari, Monserrato, Cagliari 09042, Italy
Alain Monnereau - 1] Environmental Epidemiology of Cancer Group, Inserm, Centre for research in Epidemiology and Population Health (CESP), U1018, Villejuif F-94807, France UMRS 1018, Univ Paris Sud, Villejuif F-94807, France Registre des hémopathies malignes de la Gironde, Institut Bergonié, Bordeaux 33076, France
Kimberly A Bertrand - 1] Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
Demetrius Albanes - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA
Tracy Lightfoot - Department of Health Sciences, University of York, York YO10 5DD, UK
Meredith Yeager - Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Gaithersburg, Maryland 20877, USA
Charles C Chung - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA
Laurie Burdett - Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Gaithersburg, Maryland 20877, USA
Amy Hutchinson - Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Gaithersburg, Maryland 20877, USA
Charles Lawrence - Health Studies Sector, Westat, Rockville, Maryland 20850, USA
Rebecca Montalvan - Health Studies Sector, Westat, Rockville, Maryland 20850, USA
Liming Liang - 1] Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts 02115, USA
Jinyan Huang - Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
Baoshan Ma - 1] Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA College of Information Science and Technology, Dalian Maritime University, Dalian 116026, China
Danylo J Villano - Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA
Ann Maria - Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA
Marina Corines - Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA
Tinu Thomas - Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA
Anne J Novak - Department of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
Ahmet Dogan - Departments of Laboratory Medicine and Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA
Mark Liebow - Department of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
Carrie A Thompson - Department of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
Thomas E Witzig - Department of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
Thomas M Habermann - Department of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
Martyn T Smith - Division of Environmental Health Sciences, University of California Berkeley School of Public Health, Berkeley, California 94720, USA
Elizabeth A Holly - Department of Epidemiology &Biostatistics, University of California San Francisco, San Francisco, California 94118, USA
Rebecca D Jackson - Division of Endocrinology, Diabetes and Metabolism, The Ohio State University, Columbus, Ohio 43210, USA
Lesley F Tinker - Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98117, USA
Hans-Olov Adami - 1] Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden
Karin E Smedby - Department of Medicine Solna, Karolinska Institutet, Stockholm 17176, Sweden
Anneclaire J De Roos - 1] Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98117, USA Department of Environmental and Occupational Health, Drexel University School of Public Health, Philadelphia, Pennsylvania 19104, USA
Patricia Hartge - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA
Lindsay M Morton - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA
Richard K Severson - Department of Family Medicine and Public Health Sciences, Wayne State University, Detroit, Michigan 48201, USA
Yolanda Benavente - 1] Unit of Infections and Cancer (UNIC), Cancer Epidemiology Research Programme, Institut Catala d'Oncologia, IDIBELL, Barcelona 8907, Spain Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Barcelona 8036, Spain
Paolo Boffetta - The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA
Paul Brennan - Group of Genetic Epidemiology, Section of Genetics, International Agency for Research on Cancer, Lyon 69372, France
Lenka Foretova - Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute and MF MU, Brno 65653, Czech Republic
Marc Maynadie - EA 4184, Registre des Hémopathies Malignes de Côte d'Or, University of Burgundy and Dijon University Hospital, Dijon 21070, France
James McKay - Genetic Cancer Susceptibility Group, Section of Genetics, International Agency for Research on Cancer, Lyon 69372, France
Anthony Staines - School of Nursing and Human Sciences, Dublin City University, Dublin 9, Ireland
W Ryan Diver - Epidemiology Research Program, American Cancer Society, Atlanta, Georgia 30303, USA
Claire M Vajdic - Prince of Wales Clinical School, University of New South Wales, Sydney, New South Wales 2052, Australia
Bruce K Armstrong - Sydney School of Public Health, The University of Sydney, Sydney, New South Wales 2006, Australia
Anne Kricker - Sydney School of Public Health, The University of Sydney, Sydney, New South Wales 2006, Australia
Tongzhang Zheng - Department of Environmental Health Sciences, Yale School of Public Health, New Haven, Connecticut 06520, USA
Theodore R Holford - Department of Biostatistics, Yale School of Public Health, New Haven, Connecticut 06520, USA
Gianluca Severi - 1] Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria 3053, Australia Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Carlton, Victoria 3010, Australia Human Genetics Foundation, Turin 10126, Italy
Paolo Vineis - 1] MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London W2 1PG, UK Human Genetics Foundation, Turin 10126, Italy
Giovanni M Ferri - Interdisciplinary Department of Medicine, University of Bari, Bari 70124, Italy
Rosalia Ricco - Department of Pathological Anatomy, University of Bari, Bari 70124, Italy
Lucia Miligi - Environmental and Occupational Epidemiology Unit, Cancer Prevention and Research Institute (ISPO), Florence 50139, Italy
Jacqueline Clavel - 1] Environmental Epidemiology of Cancer Group, Inserm, Centre for research in Epidemiology and Population Health (CESP), U1018, Villejuif F-94807, France UMRS 1018, Univ Paris Sud, Villejuif F-94807, France
Edward Giovannucci - 1] Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA
Peter Kraft - 1] Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts 02115, USA
Jarmo Virtamo - Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki FI-00271, Finland
Alex Smith - Department of Health Sciences, University of York, York YO10 5DD, UK
Eleanor Kane - Department of Health Sciences, University of York, York YO10 5DD, UK
Eve Roman - Department of Health Sciences, University of York, York YO10 5DD, UK
Brian C H Chiu - Department of Health Studies, University of Chicago, Chicago, Illinois 60637, USA
Joseph F Fraumeni - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA
Xifeng Wu - Department of Epidemiology, M.D. Anderson Cancer Center, Houston, Texas 77030, USA
Kenneth Offit - Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA
Stephen J Chanock - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA
Nathaniel Rothman - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA
Alexandra Nieters - Center For Chronic Immunodeficiency, University Medical Center Freiburg, Freiburg 79108, Germany
Resource Type: Journal article
Publication Details: Nature communications, Vol.6(1), pp.5751-5751
DOI: 10.1038/ncomms6751
PMID: 25569183
PMCID: PMC4287989
NLM abbreviation: Nat Commun
ISSN: 2041-1723
eISSN: 2041-1723
Grant note: R01 CA092153 / NCI NIH HHS UL1 TR000142 / NCATS NIH HHS U58 DP000807 / NCCDPHP CDC HHS R01 CA154643 / NCI NIH HHS HHSN268201100004I / NHLBI NIH HHS CA87969 / NCI NIH HHS R01 CA062006 / NCI NIH HHS ES000260 / NIEHS NIH HHS U01 CA049449 / NCI NIH HHS HHSN268201100004C / WHI NIH HHS R01 CA098122 / NCI NIH HHS Intramural NIH HHS HHSN268201100002C / WHI NIH HHS HHSN261201000035C / NCI NIH HHS N01-PC-67009 / NCI NIH HHS N01CO12400 / NCI NIH HHS HHSN268201100003C / WHI NIH HHS P50 CA97274 / NCI NIH HHS R21 CA178800 / NCI NIH HHS P30 ES000260 / NIEHS NIH HHS N02-PC-71105 / NCI NIH HHS UL1 TR000135 / NCATS NIH HHS R01CA1046282 / NCI NIH HHS P01 CA087969 / NCI NIH HHS CA098122 / NCI NIH HHS HHSN268201100046C / NHLBI NIH HHS R25 CA098566 / NCI NIH HHS P30 CA016359 / NCI NIH HHS CA49449 / NCI NIH HHS 5R01 CA69669-02 / NCI NIH HHS HHSN261201000035I / NCI NIH HHS CA098566 / NCI NIH HHS HHSN271201100004C / NIA NIH HHS U01 HG007033 / NHGRI NIH HHS P30 CA033572 / NCI NIH HHS CA97274 / NCI NIH HHS N01 PC067008 / NCI NIH HHS N01 PC065064 / NCI NIH HHS P30 CA015083 / NCI NIH HHS P50 CA097274 / NCI NIH HHS CA149445 / NCI NIH HHS P30 CA016672 / NCI NIH HHS HHSN261201000140C / NCI NIH HHS R01 CA129539 / NCI NIH HHS #1U58 DP000807-01 / NCCDPHP CDC HHS N01-RC-45035 / CCR NIH HHS UM1 CA167552 / NCI NIH HHS R01 CA098661 / NCI NIH HHS HHSN268201100002I / NHLBI NIH HHS N01 PC067010 / NCI NIH HHS HHSN268201100001C / WHI NIH HHS R01CA154643 / NCI NIH HHS CIHR UM1 CA182934 / NCI NIH HHS HHSN261201000034C / NCI NIH HHS N01 CN045165 / NCI NIH HHS UL1 TR000430 / NCATS NIH HHS P30 CA008748 / NCI NIH HHS CA167552 / NCI NIH HHS K07 CA115687 / NCI NIH HHS R01 CA149445 / NCI NIH HHS HHSN268201100001I / NHLBI NIH HHS R01 CA049449 / NCI NIH HHS N01RC37004 / CCR NIH HHS P30 CA016087 / NCI NIH HHS N01 PC067009 / NCI NIH HHS
Language: English
Date published: 01/08/2015
Academic Unit: Hematology, Oncology, and Blood & Marrow Transplantation; Epidemiology; Pharmaceutical Sciences and Experimental Therapeutics; Internal Medicine
Record Identifier: 9984094386002771

Metrics

24 Record Views

52 Times Cited - Web of Science