Journal article
A genome-wide meta-analysis of nodular sclerosing Hodgkin lymphoma identifies risk loci at 6p21.32
Blood, Vol.119(2), pp.469-475
01/12/2012
DOI: 10.1182/blood-2011-03-343921
PMCID: PMC3257012
PMID: 22086417
Abstract
Nodular sclerosing Hodgkin lymphoma (NSHL) is a distinct, highly heritable Hodgkin lymphoma subtype. We undertook a genome-wide meta-analysis of 393 European-origin adolescent/young adult NSHL patients and 3315 controls using the Illumina Human610-Quad Beadchip and Affymetrix Genome-Wide Human SNP Array 6.0. We identified 3 single nucleotide polymorphisms (SNPs) on chromosome 6p21.32 that were significantly associated with NSHL risk: rs9268542 (
P
= 5.35 × 10
−10
), rs204999 (
P
= 1.44 × 10
−9
), and rs2858870 (
P
= 1.69 × 10
−8
). We also confirmed a previously reported association in the same region, rs6903608 (
P
= 3.52 × 10
−10
). rs204999 and rs2858870 were weakly correlated (r
2
= 0.257), and the remaining pairs of SNPs were not correlated (r
2
< 0.1). In an independent set of 113 NSHL cases and 214 controls, 2 SNPs were significantly associated with NSHL and a third showed a comparable odds ratio (OR). These SNPs are found on 2 haplotypes associated with NSHL risk (rs204999-rs9268528-rs9268542-rs6903608-rs2858870; AGGCT, OR = 1.7,
P
= 1.71 × 10
−6
; GAATC, OR = 0.4,
P
= 1.16 × 10
−4
). All individuals with the GAATC haplotype also carried the HLA class II DRB1*0701 allele. In a separate analysis, the DRB1*0701 allele was associated with a decreased risk of NSHL (OR = 0.5, 95% confidence interval = 0.4, 0.7). These data support the importance of the HLA class II region in NSHL etiology.
Details
- Title: Subtitle
- A genome-wide meta-analysis of nodular sclerosing Hodgkin lymphoma identifies risk loci at 6p21.32
- Creators
- Wendy Cozen - Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CADalin Li - Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CATimothy Best - Committee on Cancer Biology, University of Chicago, Chicago, ILDavid J Van Den Berg - Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CAPierre-Antoine Gourraud - Department of Neurology, University of California–San Francisco School of Medicine, San Francisco, CAVictoria K Cortessis - Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CAAndrew D Skol - Department of Medicine, University of Chicago, Chicago, ILThomas M Mack - Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CASally L Glaser - Cancer Prevention Institute of California, Fremont, CALawrence M Weiss - Department of Pathology, City of Hope National Medical Center and City of Hope Comprehensive Cancer Center, Duarte, CABharat N Nathwani - Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, CASmita Bhatia - Department of Population Sciences, City of Hope National Medical Center and City of Hope Comprehensive Cancer Center, Duarte, CAFredrick R Schumacher - Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CAChristopher K Edlund - Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CAAmie E Hwang - Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CASusan L Slager - Mayo Clinic School of Medicine, Rochester, MNZachary S Fredericksen - Mayo Clinic School of Medicine, Rochester, MNLouise C Strong - Department of Genetics, The University of Texas M. D. Anderson Cancer Center, Houston, TXThomas M Habermann - Mayo Clinic School of Medicine, Rochester, MNBrian K Link - Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, IAJames R Cerhan - Mayo Clinic School of Medicine, Rochester, MNLeslie L Robison - Department of Epidemiology and Cancer Control, St Jude Children's Research Hospital, Memphis, TN; andDavid V Conti - Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CAKenan Onel - Committee on Cancer Biology, University of Chicago, Chicago, IL
- Resource Type
- Journal article
- Publication Details
- Blood, Vol.119(2), pp.469-475
- DOI
- 10.1182/blood-2011-03-343921
- PMID
- 22086417
- PMCID
- PMC3257012
- NLM abbreviation
- Blood
- ISSN
- 0006-4971
- eISSN
- 1528-0020
- Publisher
- American Society of Hematology
- Grant note
- CA110836; HD0433871; CA129045; CA40046; CA55727; CA58839; N01-PC-35139; N01-PC-35136 / National Institutes of Health
- Language
- English
- Date published
- 01/12/2012
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Epidemiology; Internal Medicine
- Record Identifier
- 9984094375102771
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