Journal article
A genome-wide screen for genes influencing conduct disorder
Molecular psychiatry, Vol.9(1), pp.81-86
01/2004
DOI: 10.1038/sj.mp.4001368
PMID: 14699444
Abstract
While behavioral genetic studies have suggested that childhood conduct disorder is under genetic influence, studies aimed at gene identification are lacking. This study represents the first genome-wide linkage analysis directed toward identifying genes contributing to conduct disorder. Genome screens of retrospectively reported childhood conduct disorder and conduct disorder symptomatology were carried out in the genetically informative adult sample collected as part of the Collaborative Study on the Genetics of Alcoholism (COGA). The results suggest that regions on chromosomes 19 and 2 may contain genes conferring risk to conduct disorder. Interestingly, the same region on chromosome 2 has also been linked to alcohol dependence in this sample. Childhood conduct disorder is known to be associated with the susceptibility for future alcohol problems. Taken together, these findings suggest that some of the genes contributing to alcohol dependence in adulthood may also contribute to conduct disorder in childhood.
Details
- Title: Subtitle
- A genome-wide screen for genes influencing conduct disorder
- Creators
- D M Dick - Indiana University, 975 West Walnut St., IB-130, Indianapolis, IN 46202-5251, USAT-K LiH J EdenbergV HesselbrockJ KramerS KupermanB PorjeszK BucholzA GoateJ NurnbergerT Foroud
- Resource Type
- Journal article
- Publication Details
- Molecular psychiatry, Vol.9(1), pp.81-86
- DOI
- 10.1038/sj.mp.4001368
- PMID
- 14699444
- NLM abbreviation
- Mol Psychiatry
- ISSN
- 1359-4184
- eISSN
- 1476-5578
- Publisher
- England
- Grant note
- M01 RR6192 / NCRR NIH HHS AA13358 / NIAAA NIH HHS K02 AA00285 / NIAAA NIH HHS U10 AA08403 / NIAAA NIH HHS
- Language
- English
- Date published
- 01/2004
- Academic Unit
- Psychiatry; Stead Family Department of Pediatrics
- Record Identifier
- 9984003940402771
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