Journal article
A genome-wide search for chromosomal loci linked to mental health wellness in relatives at high risk for bipolar affective disorder among the Old Order Amish
Proceedings of the National Academy of Sciences - PNAS, Vol.95(26), pp.15531-15536
12/22/1998
DOI: 10.1073/pnas.95.26.15531
PMCID: PMC28077
PMID: 9861003
Abstract
Bipolar affective disorder (BPAD; manic-depressive illness) is characterized by episodes of mania and/or hypomania interspersed with periods of depression. Compelling evidence supports a significant genetic component in the susceptibility to develop BPAD. To date, however, linkage studies have attempted only to identify chromosomal loci that cause or increase the risk of developing BPAD. To determine whether there could be protective alleles that prevent or reduce the risk of developing BPAD, similar to what is observed in other genetic disorders, we used mental health wellness (absence of any psychiatric disorder) as the phenotype in our genome-wide linkage scan of several large multigeneration Old Order Amish pedigrees exhibiting an extremely high incidence of BPAD. We have found strong evidence for a locus on chromosome 4p at
Details
- Title: Subtitle
- A genome-wide search for chromosomal loci linked to mental health wellness in relatives at high risk for bipolar affective disorder among the Old Order Amish
- Creators
- Edward I Ginns - Departments of Psychiatry, Pharmacology, and Toxicology, Indiana University School of Medicine and Lilly Research Laboratories, Eli Lilly and Co., Indianapolis, IN 46285Pamela St. Jean - Departments of Psychiatry, Pharmacology, and Toxicology, Indiana University School of Medicine and Lilly Research Laboratories, Eli Lilly and Co., Indianapolis, IN 46285Robert A Philibert - Departments of Psychiatry, Pharmacology, and Toxicology, Indiana University School of Medicine and Lilly Research Laboratories, Eli Lilly and Co., Indianapolis, IN 46285Marzena Galdzicka - Departments of Psychiatry, Pharmacology, and Toxicology, Indiana University School of Medicine and Lilly Research Laboratories, Eli Lilly and Co., Indianapolis, IN 46285Patricia Damschroder-Williams - Departments of Psychiatry, Pharmacology, and Toxicology, Indiana University School of Medicine and Lilly Research Laboratories, Eli Lilly and Co., Indianapolis, IN 46285Bonnie Thiel - Departments of Psychiatry, Pharmacology, and Toxicology, Indiana University School of Medicine and Lilly Research Laboratories, Eli Lilly and Co., Indianapolis, IN 46285Robert T Long - Departments of Psychiatry, Pharmacology, and Toxicology, Indiana University School of Medicine and Lilly Research Laboratories, Eli Lilly and Co., Indianapolis, IN 46285Loring J Ingraham - Departments of Psychiatry, Pharmacology, and Toxicology, Indiana University School of Medicine and Lilly Research Laboratories, Eli Lilly and Co., Indianapolis, IN 46285Harnisha Dalwaldi - Departments of Psychiatry, Pharmacology, and Toxicology, Indiana University School of Medicine and Lilly Research Laboratories, Eli Lilly and Co., Indianapolis, IN 46285Melissa A Murray - Departments of Psychiatry, Pharmacology, and Toxicology, Indiana University School of Medicine and Lilly Research Laboratories, Eli Lilly and Co., Indianapolis, IN 46285Melissa Ehlert - Departments of Psychiatry, Pharmacology, and Toxicology, Indiana University School of Medicine and Lilly Research Laboratories, Eli Lilly and Co., Indianapolis, IN 46285Sharon Paul - Departments of Psychiatry, Pharmacology, and Toxicology, Indiana University School of Medicine and Lilly Research Laboratories, Eli Lilly and Co., Indianapolis, IN 46285Brian G Remortel - Departments of Psychiatry, Pharmacology, and Toxicology, Indiana University School of Medicine and Lilly Research Laboratories, Eli Lilly and Co., Indianapolis, IN 46285Ashima P Patel - Departments of Psychiatry, Pharmacology, and Toxicology, Indiana University School of Medicine and Lilly Research Laboratories, Eli Lilly and Co., Indianapolis, IN 46285Maria C. H Anderson - Departments of Psychiatry, Pharmacology, and Toxicology, Indiana University School of Medicine and Lilly Research Laboratories, Eli Lilly and Co., Indianapolis, IN 46285Cary Shaio - Departments of Psychiatry, Pharmacology, and Toxicology, Indiana University School of Medicine and Lilly Research Laboratories, Eli Lilly and Co., Indianapolis, IN 46285Elaine Lau - Departments of Psychiatry, Pharmacology, and Toxicology, Indiana University School of Medicine and Lilly Research Laboratories, Eli Lilly and Co., Indianapolis, IN 46285Inna Dymarskaia - Departments of Psychiatry, Pharmacology, and Toxicology, Indiana University School of Medicine and Lilly Research Laboratories, Eli Lilly and Co., Indianapolis, IN 46285Brian M Martin - Departments of Psychiatry, Pharmacology, and Toxicology, Indiana University School of Medicine and Lilly Research Laboratories, Eli Lilly and Co., Indianapolis, IN 46285Barbara Stubblefield - Departments of Psychiatry, Pharmacology, and Toxicology, Indiana University School of Medicine and Lilly Research Laboratories, Eli Lilly and Co., Indianapolis, IN 46285Kathleen M Falls - Departments of Psychiatry, Pharmacology, and Toxicology, Indiana University School of Medicine and Lilly Research Laboratories, Eli Lilly and Co., Indianapolis, IN 46285John P Carulli - Departments of Psychiatry, Pharmacology, and Toxicology, Indiana University School of Medicine and Lilly Research Laboratories, Eli Lilly and Co., Indianapolis, IN 46285Tim P Keith - Departments of Psychiatry, Pharmacology, and Toxicology, Indiana University School of Medicine and Lilly Research Laboratories, Eli Lilly and Co., Indianapolis, IN 46285Cathy S. J Fann - Departments of Psychiatry, Pharmacology, and Toxicology, Indiana University School of Medicine and Lilly Research Laboratories, Eli Lilly and Co., Indianapolis, IN 46285Lucy G Lacy - Departments of Psychiatry, Pharmacology, and Toxicology, Indiana University School of Medicine and Lilly Research Laboratories, Eli Lilly and Co., Indianapolis, IN 46285Cleona R Allen - Departments of Psychiatry, Pharmacology, and Toxicology, Indiana University School of Medicine and Lilly Research Laboratories, Eli Lilly and Co., Indianapolis, IN 46285Abram M Hostetter - Departments of Psychiatry, Pharmacology, and Toxicology, Indiana University School of Medicine and Lilly Research Laboratories, Eli Lilly and Co., Indianapolis, IN 46285Robert C Elston - Departments of Psychiatry, Pharmacology, and Toxicology, Indiana University School of Medicine and Lilly Research Laboratories, Eli Lilly and Co., Indianapolis, IN 46285Nicholas J Schork - Departments of Psychiatry, Pharmacology, and Toxicology, Indiana University School of Medicine and Lilly Research Laboratories, Eli Lilly and Co., Indianapolis, IN 46285Janice A Egeland - Departments of Psychiatry, Pharmacology, and Toxicology, Indiana University School of Medicine and Lilly Research Laboratories, Eli Lilly and Co., Indianapolis, IN 46285Steven M Paul - Departments of Psychiatry, Pharmacology, and Toxicology, Indiana University School of Medicine and Lilly Research Laboratories, Eli Lilly and Co., Indianapolis, IN 46285
- Resource Type
- Journal article
- Publication Details
- Proceedings of the National Academy of Sciences - PNAS, Vol.95(26), pp.15531-15536
- DOI
- 10.1073/pnas.95.26.15531
- PMID
- 9861003
- PMCID
- PMC28077
- NLM abbreviation
- Proc Natl Acad Sci U S A
- ISSN
- 0027-8424
- eISSN
- 1091-6490
- Publisher
- National Academy of Sciences
- Language
- English
- Date published
- 12/22/1998
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Psychiatry; Iowa Neuroscience Institute
- Record Identifier
- 9984003940102771
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