A genome-wide sib-pair scan for quantitative language traits reveals linkage to chromosomes 10 and 13

P D Evans; K L Mueller; E R Gamazon; N J Cox; J B Tomblin

doi:10.1111/gbb.12223

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A genome-wide sib-pair scan for quantitative language traits reveals linkage to chromosomes 10 and 13

Journal article

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A genome-wide sib-pair scan for quantitative language traits reveals linkage to chromosomes 10 and 13

P D Evans, K L Mueller, E R Gamazon, N J Cox and J B Tomblin

Genes, brain and behavior, Vol.14(5), pp.387-397

06/2015

DOI: 10.1111/gbb.12223

PMCID: PMC4755290

PMID: 25997078

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Abstract

Although there is considerable evidence that individual differences in language development are highly heritable, there have been few genome-wide scans to locate genes associated with the trait. Previous analyses of language impairment have yielded replicable evidence for linkage to regions on chromosomes 16q, 19q, 13q (within lab) and at 13q (between labs). Here we report the first linkage study to screen the continuum of language ability, from normal to disordered, as found in the general population. 383 children from 147 sib-ships (214 sib-pairs) were genotyped on the Illumina(®) Linkage IVb Marker Panel using three composite language-related phenotypes and a measure of phonological memory (PM). Two regions (10q23.33; 13q33.3) yielded genome-wide significant peaks for linkage with PM. A peak suggestive of linkage was also found at 17q12 for the overall language composite. This study presents two novel genetic loci for the study of language development and disorders, but fails to replicate findings by previous groups. Possible reasons for this are discussed.

Chromosomes, Human, Pair 13 - genetics

Chromosomes, Human, Pair 19 - genetics

Genome-Wide Association Study

Phenotype

Humans

Language Development

Female

Male

Quantitative Trait Loci

Child

Chromosomes, Human, Pair 16 - genetics

Genetic Linkage

Details

Title: Subtitle: A genome-wide sib-pair scan for quantitative language traits reveals linkage to chromosomes 10 and 13
Creators: P D Evans - Department of Medicine, The University of Chicago, IL, USA
K L Mueller - Department of Communication Sciences and Disorders, The University of Iowa, IA, USA
E R Gamazon - Present address: Division of Genetic Medicine, Department of Medicine, Vanderbilt University, Nashville, TN, USA
N J Cox - Present address: Division of Genetic Medicine, Department of Medicine, Vanderbilt University, Nashville, TN, USA
J B Tomblin - Department of Communication Sciences and Disorders, The University of Iowa, IA, USA
Resource Type: Journal article
Publication Details: Genes, brain and behavior, Vol.14(5), pp.387-397
DOI: 10.1111/gbb.12223
PMID: 25997078
PMCID: PMC4755290
NLM abbreviation: Genes Brain Behav
ISSN: 1601-1848
eISSN: 1601-183X
Publisher: England
Grant note: P50 DC002746 / NIDCD NIH HHS R01 DC000496 / NIDCD NIH HHS DC02746 / NIDCD NIH HHS DC00496 / NIDCD NIH HHS
Language: English
Date published: 06/2015
Academic Unit: Communication Sciences and Disorders; Iowa Neuroscience Institute
Record Identifier: 9984070156902771

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