Journal article
A graphical analysis method to estimate blood-to-tissue transfer constants for tracers with labeled metabolites
The Journal of nuclear medicine (1978), Vol.37(12), pp.2049-2057
1996
PMID: 8970533
Abstract
The Patlak graphical analysis technique is a popular tool for estimating blood-to-tissue transfer constants from multiple-time uptake data. Our objective was to extend this technique to tracers with labeled metabolites, the presence of which can cause errors in the standard Patlak analysis.
Methods: Based on previously described formulations, we generalized the graphical technique for use under specific conditions. To test the extended graphical approach, we applied the method to both simulated and patient data using a preliminary compartmental model for the PET tumor proliferation marker, 2-[11C]-thymidine.
Results: When given conditions are met, a linear relationship exists between the normalized tissue activity (tissue activity/blood activity) and a new set of graphical analysis basis functions, including a new definition of normalized time, which takes the presence of labeled metabolites into account. Graphical estimations of the tumor thymidine incorporation rate for simulated data were accurate and showed close agreement to the results of detailed compartmental analysis. In patient studies, the graphical and compartmental estimates showed good agreement but a somewhat poorer correlation than in the simulations.
Conclusion: The extended graphical analysis approach provides an efficient method for estimating blood-tissue transfer constants for tracers with labeled metabolites.
Details
- Title: Subtitle
- A graphical analysis method to estimate blood-to-tissue transfer constants for tracers with labeled metabolites
- Creators
- David A Mankoff - Division of Nuclear Medicine, University of Washington, Seattle, Washington, United StatesAnthony F Shields - Division of Nuclear Medicine, University of Washington, Seattle, Washington, United StatesMichael M Graham - Division of Nuclear Medicine, University of Washington, Seattle, Washington, United StatesJeanne M Link - Division of Nuclear Medicine, University of Washington, Seattle, Washington, United StatesKenneth A Krohn - Division of Nuclear Medicine, University of Washington, Seattle, Washington, United States
- Resource Type
- Journal article
- Publication Details
- The Journal of nuclear medicine (1978), Vol.37(12), pp.2049-2057
- Publisher
- Society of Nuclear Medicine; Reston, VA
- PMID
- 8970533
- ISSN
- 0161-5505
- eISSN
- 1535-5667
- Language
- English
- Date published
- 1996
- Academic Unit
- Radiology; Radiation Oncology
- Record Identifier
- 9984047644002771
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