Journal article
A head start: The relationship of placental factors to craniofacial and brain development
Developmental dynamics, Vol.254(10), pp.1096-1114
10/2025
DOI: 10.1002/dvdy.70018
PMCID: PMC12353629
PMID: 40105397
Appears in UI Libraries Support Open Access
Abstract
In recent years, the importance of placental function for fetal neurodevelopment has become increasingly studied. This field, known as neuroplacentology, has greatly expanded possible etiologies of neurodevelopmental disorders by exploring the influence of placental function on brain development. It is also well-established that brain development is influenced by craniofacial morphogenesis. However, there is less focus on the impact of the placenta on craniofacial development. Recent research suggests the functional influence of placental nutrients and hormones on craniofacial skeletal growth, such as prolactin, growth hormone, insulin-like growth factor 1, vitamin D, sulfate, and calcium, impacting both craniofacial and brain development. Therefore, interactions between the placenta and both fetal neurodevelopment and craniofacial development likely influence the growth and morphology of the head as a whole. This review discusses the role of placental hormone production and nutrient delivery in the development of the fetal head-defined as craniofacial and brain tissue together-expanding on the more established focus on brain development to also include the skull (or cranium) and face.
Details
- Title: Subtitle
- A head start: The relationship of placental factors to craniofacial and brain development
- Creators
- Annemarie Jenna Carver - University of IowaMartine Dunnwald - University of IowaHanna Elizabeth Stevens - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Developmental dynamics, Vol.254(10), pp.1096-1114
- DOI
- 10.1002/dvdy.70018
- PMID
- 40105397
- PMCID
- PMC12353629
- NLM abbreviation
- Dev Dyn
- ISSN
- 1097-0177
- eISSN
- 1097-0177
- Publisher
- Wiley
- Grant note
- IOS2414883 / National Science Foundation T32GM145441 / NCATS NIH HHS NIGMS NIH HHS T32GM008629 / NCATS NIH HHS R01 MH119165 / NIMH NIH HHS R03TR004674 / NCATS NIH HHS
- Language
- English
- Electronic publication date
- 03/19/2025
- Date published
- 10/2025
- Academic Unit
- Psychiatry; Anatomy and Cell Biology; Iowa Neuroscience Institute; Craniofacial Anomalies Research Center
- Record Identifier
- 9984802012902771
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