Journal article
A heart-like Na+ current in the medial entorhinal cortex
Neuron (Cambridge, Mass.), Vol.11(6), pp.1037-1047
12/1993
DOI: 10.1016/0896-6273(93)90217-F
PMID: 8274275
Abstract
Acutely dissociated neurons from the superficial layers of the medial entorhinal cortex of the rat were studied under voltage clamp using the whole-cell patch-clamp configuration. Neurons from the medial entorhinal cortex exhibit a tetrodotoxin (TTX)-resistant Na+ current (ITTX-R; IC50 approximately 146 nM), in addition to the normal TTX-sensitive Na+ current (ITTX-S; IC50 approximately 6 nM). ITTX-R was found in both putative stellate and putative pyramidal neurons from the medial entorhinal cortex. ITTX-R is kinetically indistinguishable from ITTX-S, but can be distinguished from ITTX-S based on its enhanced sensitivity to block by Cd2+, La3+, and Zn2+. ITTX-R is kinetically and pharmacologically similar to the TTX-resistant Na+ current found in cardiac muscle.
Details
- Title: Subtitle
- A heart-like Na+ current in the medial entorhinal cortex
- Creators
- John A White - Department of Biological Sciences, University of Iowa, Iowa City 52242-1324Angel AlonsoAlan R Kay
- Resource Type
- Journal article
- Publication Details
- Neuron (Cambridge, Mass.), Vol.11(6), pp.1037-1047
- DOI
- 10.1016/0896-6273(93)90217-F
- PMID
- 8274275
- NLM abbreviation
- Neuron
- ISSN
- 0896-6273
- eISSN
- 1097-4199
- Publisher
- United States
- Language
- English
- Date published
- 12/1993
- Academic Unit
- Iowa Neuroscience Institute; Biology
- Record Identifier
- 9983992045002771
Metrics
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