Journal article
A high-density microsatellite map of the ataxia-telangiectasia locus
Human genetics, Vol.95(4), pp.451-454
04/1995
DOI: 10.1007/BF00208975
PMID: 7705845
Abstract
The locus of the autosomal recessive disorder ataxia-telangiectasia (A-T) has been assigned by linkage analysis with biallelic markers to a 4-Mb interval on chromosome 11q22-23, between GRIA4 and D11S1897. We have undertaken to saturate the A-T region with highly polymorphic microsatellite markers. To this end, we have identified seven new polymorphic CA-repeats in this region, and have mapped to it five new markers generated by Genethon and the Cooperative Human Linkage Center. These markers are in addition to 12 others that we have previously mapped or generated at the A-T locus. All 24 markers have been integrated into a high-density microsatellite map spanning some 6 Mb DNA. This map, which contains the A-T locus and flanking sequences, allows the construction of extensive, highly informative haplotypes.
Details
- Title: Subtitle
- A high-density microsatellite map of the ataxia-telangiectasia locus
- Creators
- Lina VanagaiteMichael R JamesGalit RotmanKinneret SavitskyAnat Bar-ShiraShlomit GiladYael ZivVitalia UchenikAdam SartielFrancis S CollinsVal C SheffieldCharles W RichardJean WeissenbachYosef Shiloh
- Resource Type
- Journal article
- Publication Details
- Human genetics, Vol.95(4), pp.451-454
- DOI
- 10.1007/BF00208975
- PMID
- 7705845
- ISSN
- 0340-6717
- eISSN
- 1432-1203
- Language
- English
- Date published
- 04/1995
- Academic Unit
- Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Medical Genetics and Genomics; Ophthalmology and Visual Sciences
- Record Identifier
- 9984065394502771
Metrics
28 Record Views