A high dosage influenza vaccine induced significantly more neuraminidase antibody than standard vaccine among elderly subjects

Thomas R Cate; Yolanda Rayford; Diane Niño; Patricia Winokur; Rebecca Brady; Robert Belshe; Wilbur Chen; Robert L Atmar; Robert B Couch

doi:10.1016/j.vaccine.2009.12.041

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A high dosage influenza vaccine induced significantly more neuraminidase antibody than standard vaccine among elderly subjects

Journal article

Open access

Peer reviewed

A high dosage influenza vaccine induced significantly more neuraminidase antibody than standard vaccine among elderly subjects

Thomas R Cate, Yolanda Rayford, Diane Niño, Patricia Winokur, Rebecca Brady, Robert Belshe, Wilbur Chen, Robert L Atmar and Robert B Couch

Vaccine, Vol.28(9), pp.2076-2079

2010

DOI: 10.1016/j.vaccine.2009.12.041

PMCID: PMC2853016

PMID: 20044052

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Abstract

Antibody to the neuraminidase (NA) antigen of influenza viruses has been shown to correlate with immunity to influenza in humans and animal models. In a previous report, we showed that an inactivated influenza vaccine containing 60 μg of the hemagglutinin (HA) of each strain induced significantly more serum anti-HA antibody among elderly persons than did the standard vaccine containing 15 μg of the HA of each component. We developed a lectin-based assay for anti-NA antibody and used it to measure anti-NA antibody responses among subjects who had participated in that study. The high dosage vaccine contained eight times as much NA activity as the standard vaccine and induced a significantly higher frequency of antibody responses and higher mean postvaccination anti-NA titers to the N1 and N2 of the A/H1N1 and A/H3N2 viruses in the vaccines than did the standard vaccine. Ensuring an increased antibody response to the NA antigen in inactivated influenza virus vaccines should increase the protection against influenza. An increased quantity of the NA antigen in the vaccine will ensure an increased response.

Antibody

Influenza vaccine

Neuraminidase

Details

Title: Subtitle: A high dosage influenza vaccine induced significantly more neuraminidase antibody than standard vaccine among elderly subjects
Creators: Thomas R Cate - Baylor College of Medicine, One Baylor Plaza, MS: BCM 280, Houston, TX 77030, United States
Yolanda Rayford - Baylor College of Medicine, One Baylor Plaza, MS: BCM 280, Houston, TX 77030, United States
Diane Niño - Baylor College of Medicine, One Baylor Plaza, MS: BCM 280, Houston, TX 77030, United States
Patricia Winokur - Carver College of Medicine, 200 CMAB, 451 Newton Road, Iowa City, IA 52242, United States
Rebecca Brady - Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, MLC 6014, Cincinnati, OH 45229-3039, United States
Robert Belshe - St. Louis University School of Medicine, Department of Internal Medicine, Division of Infectious Diseases, Edward A. Doisy Research Center, 8th Floor, 1100 S. Grand Boulevard, St. Louis, MO 63104, United States
Wilbur Chen - University of Maryland School of Medicine, 685W. Baltimore Street, Suite 480, Baltimore MD 21201, United States
Robert L Atmar - Baylor College of Medicine, One Baylor Plaza, MS: BCM 280, Houston, TX 77030, United States
Robert B Couch - Baylor College of Medicine, One Baylor Plaza, MS: BCM 280, Houston, TX 77030, United States
Resource Type: Journal article
Publication Details: Vaccine, Vol.28(9), pp.2076-2079
DOI: 10.1016/j.vaccine.2009.12.041
PMID: 20044052
PMCID: PMC2853016
NLM abbreviation: Vaccine
ISSN: 0264-410X
eISSN: 1873-2518
Publisher: Elsevier Ltd
Language: English
Date published: 2010
Academic Unit: Infectious Diseases; Medicine Administration; Internal Medicine
Record Identifier: 9984094639402771

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