Journal article
A higher aspect ratio enhanced bioaccumulation and altered immune responses due to intravenously-injected aluminum oxide nanoparticles
Journal of immunotoxicology, Vol.13(4), pp.439-448
07/03/2016
DOI: 10.3109/1547691X.2015.1122116
PMID: 27042761
Abstract
Aluminum oxide nanoparticles (AlO NP) have been widely utilized in a variety of areas, including in the optical, biomedical and electronic fields and in the overall development of nanotechnologies. However, their toxicological profiles are still not fully developed. This study compared the distribution and immunotoxicity of two rod-types of AlO NP. As reported previously, the two types of AlO NP had different aspect ratios (long-type: 6.2 ± 0.6, short-type: 2.1 ± 0.4), but the size and surface charge were very similar. On Day 14 after a single intravenous (IV) injection (1.25 or 5 mg/kg), both AlO NP accumulated primarily in the liver and spleen and altered the levels of redox response-related elements. The accumulated level was higher in mice exposed to the long-type AlO NP compared to the short-type. Additionally, it was noted that the levels of IL-1β, IL-8 and MCP-1 were enhanced in the blood of mice exposed to both types of AlO NP and the percentages of neutrophils and monocytes among all white blood cells were increased only in mice injected with the long-type AlO NP (5 mg/kg). In addition, as compared to the control, co-expression of CD80 and CD86 (necessary for antigen presentation) on splenocytes together with a decreased expression of chemotaxis-related marker (CD195) was attenuated by exposure to the AlO NP, especially the long-type. Taken together, the data suggest that accumulation following a single IV injection with rod-types of AlO NP is strengthened by a high aspect ratio and, subsequently, this accumulation has the potential to influence immune functions in an exposed host.
Details
- Title: Subtitle
- A higher aspect ratio enhanced bioaccumulation and altered immune responses due to intravenously-injected aluminum oxide nanoparticles
- Creators
- Eun-Jung Park - Myunggok Eye Research Institute, Konyang UniversitySoo Nam Kim - Toxicologic Pathology Center, Korea Institute of ToxicologyMin-Sung Kang - Toxicologic Pathology Center, Korea Institute of ToxicologyByoung-Seok Lee - Toxicologic Pathology Center, Korea Institute of ToxicologyCheolho Yoon - Seoul Center, Korea Basic Science InstituteUiseok Jeong - Department of Chemical Engineering, Kwangwoon UniversityYounghun Kim - Department of Chemical Engineering, Kwangwoon UniversityGwang-Hee Lee - School of Civil, Environmental and Architectural Engineering, Korea UniversityDong-Wan Kim - School of Civil, Environmental and Architectural Engineering, Korea UniversityJong Sung Kim - Department of Community Health and Epidemiology, Faculty of Medicine, Dalhousie University
- Resource Type
- Journal article
- Publication Details
- Journal of immunotoxicology, Vol.13(4), pp.439-448
- Publisher
- Taylor & Francis
- DOI
- 10.3109/1547691X.2015.1122116
- PMID
- 27042761
- ISSN
- 1547-691X
- eISSN
- 1547-6901
- Language
- English
- Date published
- 07/03/2016
- Academic Unit
- Occupational and Environmental Health
- Record Identifier
- 9984214946202771
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