A human prefrontal-subthalamic circuit for cognitive control

Ryan Kelley; Oliver Flouty; Eric B Emmons; Youngcho Kim; Johnathan Kingyon; Jan R Wessel; Hiroyuki Oya; Jeremy D Greenlee; Nandakumar S Narayanan

doi:10.1093/brain/awx300

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A human prefrontal-subthalamic circuit for cognitive control

Journal article

Open access

Peer reviewed

A human prefrontal-subthalamic circuit for cognitive control

Ryan Kelley, Oliver Flouty, Eric B Emmons, Youngcho Kim, Johnathan Kingyon, Jan R Wessel, Hiroyuki Oya, Jeremy D Greenlee and Nandakumar S Narayanan

Brain (London, England : 1878), Vol.141(1), pp.205-216

01/01/2018

DOI: 10.1093/brain/awx300

PMCID: PMC5837669

PMID: 29190362

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Abstract

The subthalamic nucleus is a key site controlling motor function in humans. Deep brain stimulation of the subthalamic nucleus can improve movements in patients with Parkinson's disease; however, for unclear reasons, it can also have cognitive effects. Here, we show that the human subthalamic nucleus is monosynaptically connected with cognitive brain areas such as the prefrontal cortex. Single neurons and field potentials in the subthalamic nucleus are modulated during cognitive processing and are coherent with 4-Hz oscillations in medial prefrontal cortex. These data predict that low-frequency deep brain stimulation may alleviate cognitive deficits in Parkinson's disease patients. In line with this idea, we found that novel 4-Hz deep brain stimulation of the subthalamic nucleus improved cognitive performance. These data support a role for the human hyperdirect pathway in cognitive control, which could have relevance for brain-stimulation therapies aimed at cognitive symptoms of human brain disease.awx300media15660002226001.

Parkinson Disease - therapy

Cognition Disorders - diagnostic imaging

Humans

Male

Electroencephalography

Neural Pathways - physiology

Cognition Disorders - etiology

Neurons - physiology

Cognition - physiology

Female

Subthalamic Nucleus - diagnostic imaging

Cues

Parkinson Disease - complications

Parkinson Disease - diagnostic imaging

Oxygen - blood

Deep Brain Stimulation - methods

Neuropsychological Tests

Magnetic Resonance Imaging

Subthalamic Nucleus - physiology

Image Processing, Computer-Assisted

Neural Pathways - diagnostic imaging

Brain Mapping

Cognition Disorders - therapy

Prefrontal Cortex - physiology

Prefrontal Cortex - diagnostic imaging

Details

Title: Subtitle: A human prefrontal-subthalamic circuit for cognitive control
Creators: Ryan Kelley - Program in Neuroscience, University of Iowa, Iowa City, IA 52242, USA
Oliver Flouty - Department of Neurosurgery, University of Iowa, Iowa City, IA 52242, USA
Eric B Emmons - Program in Neuroscience, University of Iowa, Iowa City, IA 52242, USA
Youngcho Kim - Department of Neurology, University of Iowa, Iowa City, IA 52242, USA
Johnathan Kingyon - Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
Jan R Wessel - Department of Neurology, University of Iowa, Iowa City, IA 52242, USA
Hiroyuki Oya - Department of Neurosurgery, University of Iowa, Iowa City, IA 52242, USA
Jeremy D Greenlee - Department of Neurosurgery, University of Iowa, Iowa City, IA 52242, USA
Nandakumar S Narayanan - Department of Neurology, University of Iowa, Iowa City, IA 52242, USA
Resource Type: Journal article
Publication Details: Brain (London, England : 1878), Vol.141(1), pp.205-216
DOI: 10.1093/brain/awx300
PMID: 29190362
PMCID: PMC5837669
NLM abbreviation: Brain
ISSN: 0006-8950
eISSN: 1460-2156
Publisher: England
Grant note: R01 NS089470 / NINDS NIH HHS R01 NS100849 / NINDS NIH HHS T35 HL007485 / NHLBI NIH HHS F31 MH110092 / NIMH NIH HHS T32 GM007337 / NIGMS NIH HHS
Language: English
Date published: 01/01/2018
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Neurology; Psychological and Brain Sciences; Iowa Neuroscience Institute; Neurosurgery; Otolaryngology
Record Identifier: 9984002488202771

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