Journal article
A human recessive neurosensory nonsyndromic hearing impairment locus is a potential homologue of the murine deafness (dn) locus
Human molecular genetics, Vol.4(12), pp.2391-2394
12/1995
DOI: 10.1093/hmg/4.12.2391
PMID: 8634715
Abstract
A locus for recessive neurosensory nonsyndromic hearing impairment maps to chromosome 9q13–q21 in two regionally separate consanguineous families from India. Each family demonstrates a LOD score greater than 4.5 to this region. D9S15, tightly linked to the Friedreich's ataxia locus, a region that has been defined with over 1 Mb of YAC contig information and several expressed sequences, is one of the flanking markers. In mice, the deafness (dn) locus maps to mouse chromosome 19 and flanking loci are syntenic to human chromosome 9q11–q21. The dn mouse is a potential model for the hearing impairment found in both these families.
Details
- Title: Subtitle
- A human recessive neurosensory nonsyndromic hearing impairment locus is a potential homologue of the murine deafness (dn) locus
- Creators
- Pawan K Jain - National Institutes of HealthKunihiro Fukushima - Molecular Otolaryngology Research Laboratories, Department of Otolaryngology, University of lowalowa City, IA 52242, USADilip Deshmukh - Rotary Deaf School, Ichalkaranji—Tilawani416 115, Dist. Kolhapur, Maharashtra StateArabandi Ramesh - University of MadrasElizabeth Thomas - All India Institute of Medical SciencesAnil K LalwaniSubrinder Kumar - All India Institute of Medical SciencesBarbara Ploplis - National Institutes of HealthHana Skarka - National Institutes of HealthC.R.Srikumari Srisailapathy - University of MadrasSigrid Wayne - Molecular Otolaryngology Research Laboratories, Department of Otolaryngology, University of lowalowa City, IA 52242, USARoss I.S Zbar - Molecular Otolaryngology Research Laboratories, Department of Otolaryngology, University of lowalowa City, IA 52242, USAIshwar C Verma - Rotary Deaf School, Ichalkaranji—Tilawani416 115, Dist. Kolhapur, Maharashtra StateRichard J.H Smith - Molecular Otolaryngology Research Laboratories, Department of Otolaryngology, University of lowalowa City, IA 52242, USAEdward R Wilcox - National Institutes of Health
- Resource Type
- Journal article
- Publication Details
- Human molecular genetics, Vol.4(12), pp.2391-2394
- DOI
- 10.1093/hmg/4.12.2391
- PMID
- 8634715
- NLM abbreviation
- Hum Mol Genet
- ISSN
- 0964-6906
- eISSN
- 1460-2083
- Publisher
- Oxford University Press
- Language
- English
- Date published
- 12/1995
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Molecular Physiology and Biophysics; Anatomy and Cell Biology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Otolaryngology; Internal Medicine
- Record Identifier
- 9984256836802771
Metrics
17 Record Views