A large-scale, energetic model of cardiovascular homeostasis predicts dynamics of arterial pressure in humans

Alexander Roytvarf; Vladimir Shusterman

doi:10.1109/TBME.2007.912668

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A large-scale, energetic model of cardiovascular homeostasis predicts dynamics of arterial pressure in humans

Journal article

Peer reviewed

A large-scale, energetic model of cardiovascular homeostasis predicts dynamics of arterial pressure in humans

Alexander Roytvarf and Vladimir Shusterman

IEEE transactions on biomedical engineering, Vol.55(2 Pt 1), pp.407-418

02/2008

DOI: 10.1109/TBME.2007.912668

PMCID: PMC2377399

PMID: 18269976

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Abstract

The energetic balance of forces in the cardiovascular system is vital to the stability of blood flow to all physiological systems in mammals. Yet, a large-scale, theoretical model, summarizing the energetic balance of major forces in a single, mathematically closed system has not been described. Although a number of computer simulations have been successfully performed with the use of analog models, the analysis of energetic balance of forces in such models is obscured by a big number of interacting elements. Hence, the goal of our study was to develop a theoretical model that represents large-scale, energetic balance in the cardiovascular system, including the energies of arterial pressure wave, blood flow, and the smooth muscle tone of arterial walls. Because the emphasis of our study was on tracking beat-to-beat changes in the balance of forces, we used a simplified representation of the blood pressure wave as a trapezoidal pressure-pulse with a strong-discontinuity leading front. This allowed significant reduction in the number of required parameters. Our approach has been validated using theoretical analysis, and its accuracy has been confirmed experimentally. The model predicted the dynamics of arterial pressure in human subjects undergoing physiological tests and provided insights into the relationships between arterial pressure and pressure wave velocity.

Cardiovascular Physiological Phenomena

Models, Cardiovascular

Computer Simulation

Humans

Diagnosis, Computer-Assisted - methods

Blood Pressure - physiology

Energy Metabolism - physiology

Blood Pressure Determination - methods

Details

Title: Subtitle: A large-scale, energetic model of cardiovascular homeostasis predicts dynamics of arterial pressure in humans
Creators: Alexander Roytvarf - Rishon le-Zion, Israel. roytvarf@013.net
Vladimir Shusterman
Resource Type: Journal article
Publication Details: IEEE transactions on biomedical engineering, Vol.55(2 Pt 1), pp.407-418
DOI: 10.1109/TBME.2007.912668
PMID: 18269976
PMCID: PMC2377399
NLM abbreviation: IEEE Trans Biomed Eng
ISSN: 0018-9294
eISSN: 1558-2531
Grant note: R44HL077116 / NHLBI NIH HHS R44 HL077116-02 / NHLBI NIH HHS R44 HL077116 / NHLBI NIH HHS
Language: English
Date published: 02/2008
Academic Unit: Cardiovascular Medicine; Internal Medicine
Record Identifier: 9984094209302771

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