A likelihood approach for quantitative-trait-locus mapping with selected pedigrees

K Wang

doi:10.1111/j.1541-0420.2005.031213.x

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A likelihood approach for quantitative-trait-locus mapping with selected pedigrees

Journal article

Peer reviewed

A likelihood approach for quantitative-trait-locus mapping with selected pedigrees

K Wang

Biometrics, Vol.61(2), pp.465-473

06/2005

DOI: 10.1111/j.1541-0420.2005.031213.x

PMID: 16011693

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Abstract

Selective sampling is a cost-effective design for mapping quantitative trait loci (QTLs). A unified framework, which naturally combines two complementary sources of linkage information in the data, is proposed for the mapping of QTLs using selected pedigrees. Score statistics for detecting linkage are introduced for single-locus models (univariate or bivariate phenotypes) and two-locus epistasis models. A computer implementation of the methods for single-locus univariate-phenotype models is provided for nuclear families with arbitrary number of sibs and is freely available.

Data Interpretation, Statistical

Quantitative Trait, Heritable

Humans

Genetic Markers

Models, Statistical

Lod Score

Linkage Disequilibrium

Likelihood Functions

Phenotype

Algorithms

Epistasis, Genetic

Pedigree

Chromosome Mapping - methods

Models, Genetic

Genetic Vectors

Quantitative Trait Loci

Genetic Linkage

Details

Title: Subtitle: A likelihood approach for quantitative-trait-locus mapping with selected pedigrees
Creators: K Wang - Program in Public Health Genetics, University of Iowa, Iowa City, Iowa 52242, USA. kai-wang@uiowa.edu
Resource Type: Journal article
Publication Details: Biometrics, Vol.61(2), pp.465-473
Publisher: United States
DOI: 10.1111/j.1541-0420.2005.031213.x
PMID: 16011693
ISSN: 0006-341X
eISSN: 1541-0420
Language: English
Date published: 06/2005
Academic Unit: Biostatistics
Record Identifier: 9983997472702771

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