Journal article
A linkage study of schizophrenia to markers within Xp11 near the MAOB gene
Psychiatry research, Vol.70(3), pp.131-143
1997
DOI: 10.1016/S0165-1781(97)03138-7
PMID: 9211575
Abstract
A sex chromosome locus for psychosis has been considered on the basis of some sex differences in genetic risk and expression of illness, and an association with X-chromosome anomalies. Previous molecular genetic studies produced weak evidence for linkage of schizophrenia to the proximal short arm of the X-chromosome, while some other regions were not ruled out. Here we report an attempt to expand the Xp findings in: (i) a multicenter collaboration focusing on 92 families with a maternal pattern of inheritance (Study I.); and (ii) an independent sample of 34 families unselected for parental mode of transmission (Study II.). In the multicenter study, a parametric analysis resulted in positive lod scores (highest of 1.97 for dominant and 1.19 for recessive inheritance at a theta of 0.20) for locus
Details
- Title: Subtitle
- A linkage study of schizophrenia to markers within Xp11 near the MAOB gene
- Creators
- Janine Dann - University Department of Psychiatry, The Warneford Hospital, Oxford, OX3 7JX, UKLynn E DeLisi - Department of Psychiatry, SUNY Stony Brook, Stony Brook, NY, 11 794, USAMarcella Devoto - Laboratory of Statistical Genetics, Rockefeller University, Box 192, 1230 York Avenue, New York, NY 10 021, USASteven Laval - University Department of Psychiatry, The Warneford Hospital, Oxford, OX3 7JX, UKDerek J Nancarrow - Queensland Institute of Medical Research, Herston, QLD 4029, AustraliaGail Shields - Department of Psychiatry, SUNY Stony Brook, Stony Brook, NY, 11 794, USAAngela Smith - Department of Psychiatry, SUNY Stony Brook, Stony Brook, NY, 11 794, USAJosephine Loftus - University Department of Psychiatry, The Warneford Hospital, Oxford, OX3 7JX, UKPaula Peterson - Department of Psychiatry, SUNY Stony Brook, Stony Brook, NY, 11 794, USAAntonio Vita - Department of Psychiatry, The University of Milan, Milan, ItalyMargherita Comazzi - Department of Psychiatry, The University of Milan, Milan, ItalyGiordano Invernizzi - Department of Psychiatry, The University of Milan, Milan, ItalyDouglas F Levinson - Department of Psychiatry, Allegheny University of the Health Sciences, Philadelphia, PA, USADieter Wildenauer - Department of Psychiatry, University of Bonn, Sigmund-Freud Str. 25, D-53 105 Bonn, GermanyBryan J Mowry - Department of Psychiatry, University of Queensland, Wolston Park Hospital, Wacol, QLD 4076, AustraliaDavid Collier - The Institute of Psychiatry, London, UKJohn Powell - The Institute of Psychiatry, London, UKRaymond R Crowe - Mental Health Clinical Research Center and College, Department of Psychiatry, University of Iowa School of Medicine, Iowa City, IA, USANancy C Andreasen - Mental Health Clinical Research Center and College, Department of Psychiatry, University of Iowa School of Medicine, Iowa City, IA, USAJeremy M Silverman - Department of Psychiatry, Mt. Sinai School of Medicine, NY, USARichard C Mohs - Department of Psychiatry, Mt. Sinai School of Medicine, NY, USARobin M Murray - The Institute of Psychiatry, London, UKMarilyn K Walters - Queensland Institute of Medical Research, Herston, QLD 4029, AustraliaDavid P Lennon - Department of Psychiatry, University of Queensland, Wolston Park Hospital, Wacol, QLD 4076, AustraliaNicholas K Hayward - Queensland Institute of Medical Research, Herston, QLD 4029, AustraliaMargot Albus - Department of Psychiatry, University of Bonn, Sigmund-Freud Str. 25, D-53 105 Bonn, GermanyBernard Lerer - Department of Psychiatry, University Medical Center, Jerusalem, IsraelWolfgang Maier - Department of Psychiatry, University of Bonn, Sigmund-Freud Str. 25, D-53 105 Bonn, GermanyTimothy J Crow - University Department of Psychiatry, The Warneford Hospital, Oxford, OX3 7JX, UK
- Resource Type
- Journal article
- Publication Details
- Psychiatry research, Vol.70(3), pp.131-143
- Publisher
- Elsevier Ireland Ltd
- DOI
- 10.1016/S0165-1781(97)03138-7
- PMID
- 9211575
- ISSN
- 0165-1781
- eISSN
- 1872-7123
- Language
- English
- Date published
- 1997
- Academic Unit
- Psychiatry; Iowa Neuroscience Institute
- Record Identifier
- 9984004185402771
Metrics
32 Record Views