A longitudinal analysis of the effect of anemia on health-related quality of life in children with mild-to-moderate chronic kidney disease

Joann Carlson; Arlene C Gerson; Matthew B Matheson; Sharon Manne; Bradley A Warady; Stephen R Hooper; Marc Lande; Lyndsay A Harshman; Rebecca J Johnson; Shlomo Shinnar; Amy J Kogon; Susan Furth

doi:10.1007/s00467-020-04569-5

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A longitudinal analysis of the effect of anemia on health-related quality of life in children with mild-to-moderate chronic kidney disease

Journal article

Peer reviewed

A longitudinal analysis of the effect of anemia on health-related quality of life in children with mild-to-moderate chronic kidney disease

Joann Carlson, Arlene C Gerson, Matthew B Matheson, Sharon Manne, Bradley A Warady, Stephen R Hooper, Marc Lande, Lyndsay A Harshman, Rebecca J Johnson, Shlomo Shinnar, …

Pediatric nephrology (Berlin, West), Vol.35(9), pp.1659-1667

04/24/2020

DOI: 10.1007/s00467-020-04569-5

PMCID: PMC8958595

PMID: 32333284

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Abstract

To evaluate impact of anemia on health-related quality of life (HRQOL) over time in a large pediatric cohort with mild-to-moderate chronic kidney disease (CKD). Participants were enrolled in the Chronic Kidney Disease in Children Study (CKiD), a multicenter, longitudinal cohort. HRQOL was measured using the Pediatric Quality of Life Inventory (PedsQL). Anemia was defined as hemoglobin < 5th percentile for age, sex, and race. Two longitudinal analyses were conducted on consecutive visit pairs. Models examined effects of anemia status on both HRQOL score over time and change in HRQOL score between consecutive visits. The sample included 733 children with a median estimated GFR 54 ml/min/1.73 m . Thirty percent of children had anemia at index visit. Analysis of HRQOL scores revealed the presence of anemia was associated with significantly lower overall HRQOL (β = - 2.90 (95% CI = - 7.74, - 0.21), p = 0.04) and physical functioning (β = - 5.72 (- 9.49, - 2.25), p = 0.001) according to children. On parent ratings, the development of anemia was associated with lower emotional functioning scores (β = - 4.87 (- 8.72, - 0.11), p = 0.045). In the second model, children who developed anemia were rated by caregivers as having more decreased physical functioning than children who remained anemia-free (β = - 3.30 per year (- 5.83, - 0.76), p = 0.01). Caregivers did not observe declines in their children's other PedsQL subscales in the presence of developed anemia. Children with resolved or persistence did not show improvement or decline in any aspect of HRQOL functioning relative to non-anemic subjects. In children with CKD, anemia has an adverse effect on HRQOL which persists over time but does not appear to be progressive.

Hemoglobin

Psychosocial

Longitudinal

PedsQL

Parent-child agreement

Kidney disease progression

Details

Title: Subtitle: A longitudinal analysis of the effect of anemia on health-related quality of life in children with mild-to-moderate chronic kidney disease
Creators: Joann Carlson - Division of Pediatric Nephrology and Hypertension, Department of Pediatrics, Rutgers/Robert Wood Johnson Medical School, New Brunswick, NJ, USA. Joann.Carlson@rutgers.edu
Arlene C Gerson - Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, MD, USA
Matthew B Matheson - Department of Epidemiology, Johns Hopkins School of Medicine, Baltimore, MD, USA
Sharon Manne - Department of Medicine, Rutgers/Robert Wood Johnson Medical School, New Brunswick, NJ, USA
Bradley A Warady - Division of Pediatric Nephrology, Department of Pediatrics, Children's Mercy Kansas City, Kansas City, MO, USA
Stephen R Hooper - Department of Allied Health Sciences, University of North Carolina School of Medicine, Chapel Hill, NC, USA
Marc Lande - Department of Pediatrics, University of Rochester Medical Center, Rochester, NY, USA
Lyndsay A Harshman - Division of Pediatric Nephrology, University of Iowa Stead Family Department of Pediatrics, University of Iowa, Iowa City, IA, USA
Rebecca J Johnson - Division of Developmental and Behavioral Health, Department of Pediatrics, Children's Mercy Kansas City, UMKC School of Medicine, Kansas City, MO, USA
Shlomo Shinnar - Department of Neurology, Pediatrics and Epidemiology and Population Health, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA
Amy J Kogon - Children's Hospital of Philadelphia, Division of Pediatric Nephrology, Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA
Susan Furth - Children's Hospital of Philadelphia, Division of Pediatric Nephrology, Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA
Resource Type: Journal article
Publication Details: Pediatric nephrology (Berlin, West), Vol.35(9), pp.1659-1667
DOI: 10.1007/s00467-020-04569-5
PMID: 32333284
PMCID: PMC8958595
NLM abbreviation: Pediatr Nephrol
ISSN: 0931-041X
eISSN: 1432-198X
Publisher: Germany
Grant note: U01-DK-66143 / NIDDK/NHLBI U01-Dk-66174 / NIDDK/NHLBI U24-DK-082194 / NIDDK/NHLBI U24-DK-66116 / NIDDK/NHLBI
Language: English
Date published: 04/24/2020
Academic Unit: Nephrology, Dialysis and Transplantation; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Radiation Oncology
Record Identifier: 9984070482402771

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