Journal article
A longitudinal study of atrazine and 2,4-D exposure and oxidative stress markers among iowa corn farmers
Environmental and molecular mutagenesis, Vol.58(1), pp.30-38
01/2017
DOI: 10.1002/em.22069
PMCID: PMC5763550
PMID: 28116766
Abstract
Reactive oxygen species, potentially formed through environmental exposures, can overwhelm an organism's antioxidant capabilities resulting in oxidative stress. Long-term oxidative stress is linked with chronic diseases. Pesticide exposures have been shown to cause oxidative stress in vivo. We utilized a longitudinal study of corn farmers and non-farming controls in Iowa to examine the impact of exposure to the widely used herbicides atrazine and 2,4-dichlorophenoxyacetic acid (2,4-D) on markers of oxidative stress. 225 urine samples were collected during five agricultural time periods (pre-planting, planting, growing, harvest, off-season) for 30 farmers who applied pesticides occupationally and 10 controls who did not; all were non-smoking men ages 40-60. Atrazine mercapturate (atrazine metabolite), 2,4-D, and oxidative stress markers (malondialdehyde [MDA], 8-hydroxy-2'-deoxyguanosine [8-OHdG], and 8-isoprostaglandin-F
[8-isoPGF]) were measured in urine. We calculated β estimates and 95% confidence intervals (95%CI) for each pesticide-oxidative stress marker combination using multivariate linear mixed-effect models for repeated measures. Farmers had higher urinary atrazine mercapturate and 2,4-D levels compared with controls. In regression models, after natural log transformation, 2,4-D was associated with elevated levels of 8-OHdG (β = 0.066, 95%CI = 0.008-0.124) and 8-isoPGF (β = 0.088, 95%CI = 0.004-0.172). 2,4-D may be associated with oxidative stress because of modest increases in 8-OHdG, a marker of oxidative DNA damage, and 8-isoPGF, a product of lipoprotein peroxidation, with recent 2,4-D exposure. Future studies should investigate the role of 2,4-D-induced oxidative stress in the pathogenesis of human diseases. Environ. Mol. Mutagen. 58:30-38, 2017. © 2016 Wiley Periodicals, Inc.
Details
- Title: Subtitle
- A longitudinal study of atrazine and 2,4-D exposure and oxidative stress markers among iowa corn farmers
- Creators
- Catherine C Lerro - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MarylandLaura E Beane Freeman - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MarylandLützen Portengen - Division of Environmental Epidemiology, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, 3508, The NetherlandsDaehee Kang - Seoul National University, Seoul, South KoreaKyoungho Lee - Samsung Health Research Institute, Samsung Electronics, Yongin-City, 446-711, South KoreaAaron Blair - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MarylandCharles F Lynch - Department of Epidemiology, University of Iowa, Iowa City, IowaBerit Bakke - Department of Occupational Health Surveillance, National Institute of Occupational Health, Oslo, NorwayAnneclaire J De Roos - Department of Environmental and Occupational Health, Drexel University Dornsife School of Public Health, Philadelphia, PennsylvaniaRoel C H Vermeulen - Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht, The Netherlands
- Resource Type
- Journal article
- Publication Details
- Environmental and molecular mutagenesis, Vol.58(1), pp.30-38
- DOI
- 10.1002/em.22069
- PMID
- 28116766
- PMCID
- PMC5763550
- NLM abbreviation
- Environ Mol Mutagen
- ISSN
- 0893-6692
- eISSN
- 1098-2280
- Publisher
- Wiley; United States
- Grant note
- Z99 CA999999 / Intramural NIH HHS P30 CA086862 / NCI NIH HHS
- Language
- English
- Date published
- 01/2017
- Academic Unit
- Epidemiology
- Record Identifier
- 9983995175702771
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