Journal article
A longitudinal study of magnetic resonance spectroscopy Huntington's disease biomarkers
Movement disorders, Vol.30(3), pp.393-401
03/2015
DOI: 10.1002/mds.26118
PMID: 25690257
Abstract
Putaminal metabolites examined using cross‐sectional magnetic resonance spectroscopy (MRS) can distinguish pre‐manifest and early Huntington's Disease (HD) individuals from controls. An ideal biomarker, however, will demonstrate longitudinal change over short durations. The objective here was to evaluate longitudinal in vivo brain metabolite profiles in HD over 24 months. Eighty‐four participants (30 controls, 25 pre‐manifest HD, 29 early HD) recruited as part of TRACK‐HD were imaged at baseline, 12 months, and 24 months using 3T MRS of left putamen. Automated putaminal volume measurement was performed simultaneously. To quantify partial volume effects, spectroscopy was performed in a second, white matter voxel adjacent to putamen in six subjects. Subjects underwent TRACK‐HD motor assessment. Statistical analyses included linear regression and one‐way analysis of variance (ANOVA). At all time‐points N‐acetyl aspartate and total N‐acetyl aspartate (NAA), neuronal integrity markers, were lower in early HD than in controls. Total NAA was lower in pre‐manifest HD than in controls, whereas the gliosis marker myo‐inositol (MI) was robustly elevated in early HD. Metabolites were stable over 24 months with no longitudinal change. Total NAA was not markedly different in adjacent white matter than putamen, arguing against partial volume confounding effects in cross‐sectional group differences. Total NAA correlations with disease burden score suggest that this metabolite may be useful in identifying neurochemical responses to therapeutic agents. We demonstrate almost consistent group differences in putaminal metabolites in HD‐affected individuals compared with controls over 24 months. Future work establishing spectroscopy as an HD biomarker should include multi‐site assessments in large, pathologically diverse cohorts. © 2015 International Parkinson and Movement Disorder Society
Details
- Title: Subtitle
- A longitudinal study of magnetic resonance spectroscopy Huntington's disease biomarkers
- Creators
- Aaron Sturrock - University of British ColumbiaCorree Laule - UBC MRI Research CentreUBC HospitalVancouver British Columbia CanadaKaty Wyper - UBC MRI Research CentreUBC HospitalVancouver British Columbia CanadaRuth A Milner - Family Research InstituteJoji Decolongon - University of British ColumbiaRachelle Dar Santos - University of British ColumbiaAllison J Coleman - University of British ColumbiaKimberley Carter - University of British ColumbiaSusan Creighton - University of British ColumbiaNatalie Bechtel - University of MünsterStefan Bohlen - University of MünsterRalf Reilmann - Department of NeurologyUniversity of MünsterMünster GermanyHans J Johnson - University of IowaMichael R Hayden - University of British ColumbiaSarah J Tabrizi - University College LondonAlex L Mackay - UBC MRI Research CentreUBC HospitalVancouver British Columbia CanadaBlair R Leavitt - University of British Columbia
- Resource Type
- Journal article
- Publication Details
- Movement disorders, Vol.30(3), pp.393-401
- DOI
- 10.1002/mds.26118
- PMID
- 25690257
- NLM abbreviation
- Mov Disord
- ISSN
- 0885-3185
- eISSN
- 1531-8257
- Number of pages
- 17
- Language
- English
- Date published
- 03/2015
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Electrical and Computer Engineering; Psychiatry
- Record Identifier
- 9984185468602771
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