A magnetic resonance imaging study of the entorhinal cortex in treatment-resistant depression

Christina P. Furtado; Jerome J. Maller; Paul B. Fitzgerald

doi:10.1016/j.pscychresns.2007.11.005

Back

A magnetic resonance imaging study of the entorhinal cortex in treatment-resistant depression

Journal article

Peer reviewed

A magnetic resonance imaging study of the entorhinal cortex in treatment-resistant depression

Christina P. Furtado, Jerome J. Maller and Paul B. Fitzgerald

Psychiatry research. Neuroimaging, Vol.163(2), pp.133-142

07/15/2008

DOI: 10.1016/j.pscychresns.2007.11.005

PMID: 18511243

View Online

Abstract

Despite a growing interest in this area, we continue to lack an understanding of the pathophysiology of depression and of treatment-resistant depression (TRD) in particular. The role of the medial temporal lobe, particularly the hippocampus, has been widely implicated in the aetiology of depression. However, related structures such as the entorhinal cortex have not been systematically examined. This research study aimed to examine possible abnormalities in the volume of the entorhinal cortex (ERC) in TRD patients. A group of 45 TRD patients and 30 healthy age- and sex-matched controls underwent magnetic resonance imaging (MRI). ERC volumes were manually traced from MRI data using ANALYZE software. An analysis of variance was conducted between subject groups and in the sexes separately while controlling for the effects of brain size via intracranial volume (ICV). Results revealed significant reductions in the volume of the left ERC of female patients. Although preliminary, our findings suggest that anatomical abnormalities in the ERC may confer vulnerability to treatment resistance. Confirmatory longitudinal studies are required to determine whether these abnormalities predate the onset of depression or are the result of a more chronic, treatment-resistant course of illness. (c) 2007 Elsevier Ireland Ltd. All rights reserved.

Clinical Neurology

Life Sciences & Biomedicine

Neuroimaging

Neurosciences & Neurology

Psychiatry

Science & Technology

Details

Title: Subtitle: A magnetic resonance imaging study of the entorhinal cortex in treatment-resistant depression
Creators: Christina P. Furtado - Monash University
Jerome J. Maller - Monash Alfred Psychiatry Research centre
Paul B. Fitzgerald - Monash University
Resource Type: Journal article
Publication Details: Psychiatry research. Neuroimaging, Vol.163(2), pp.133-142
DOI: 10.1016/j.pscychresns.2007.11.005
PMID: 18511243
NLM abbreviation: Psychiatry Res Neuroimaging
ISSN: 0925-4927
eISSN: 1872-7506
Publisher: Elsevier
Number of pages: 10
Language: English
Date published: 07/15/2008
Academic Unit: Radiology
Record Identifier: 9984848501202771

Metrics

4 Record Views