A matched case-control study of IBD-associated colorectal cancer: IBD portends worse outcome

Jennifer E Hrabe; John C Byrn; Anna M Button; Gideon K Zamba; Muneera R Kapadia; James J Mezhir

doi:10.1002/jso.23465

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A matched case-control study of IBD-associated colorectal cancer: IBD portends worse outcome

Journal article

Peer reviewed

A matched case-control study of IBD-associated colorectal cancer: IBD portends worse outcome

Jennifer E Hrabe, John C Byrn, Anna M Button, Gideon K Zamba, Muneera R Kapadia and James J Mezhir

Journal of surgical oncology, Vol.109(2), pp.117-121

02/2014

DOI: 10.1002/jso.23465

PMID: 24132737

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Abstract

The effect of inflammatory bowel disease (IBD) on outcome in patients with colorectal cancer (CRC) remains unclear. Our objective is to evaluate oncologic outcomes of patients with IBD-associated CRC. We retrospectively reviewed a prospectively maintained database to identify patients with IBD-associated CRC. Clinicopathologic variables and overall survival were compared to patients with sporadic CRC using a 2:1 matched-controlled analysis. Fifty-five patients with IBD and CRC were identified. On univariate analysis, CRC patients with IBD had a significantly shorter median overall survival (68.2 months vs. 204.3 months, P = 0.01) compared to patients with sporadic CRC. On multivariate analysis, after adjusting for N and M stage, IBD was associated with an increased risk of death compared to sporadic CRC (HR = 2.011, 95% CI 1.24-3.23, P = 0.004). Stage 3 CRC patients with IBD in particular showed significantly decreased survival (23.0 vs. 133.9 months, P = 0.008). In this study, patients with node-positive IBD-associated CRC had a significant increased risk of death and a shorter overall survival than those with sporadic disease and may require tailored adjuvant therapy and surveillance protocols. Continued investigation to elucidate the mechanisms that contribute to these observations is justified.

Colorectal Neoplasms - mortality

Multivariate Analysis

Humans

Middle Aged

Kaplan-Meier Estimate

Male

Lymphatic Metastasis

Case-Control Studies

Young Adult

Adult

Female

Registries

Aged

Colorectal Neoplasms - complications

Retrospective Studies

Colorectal Neoplasms - pathology

Inflammatory Bowel Diseases - complications

Details

Title: Subtitle: A matched case-control study of IBD-associated colorectal cancer: IBD portends worse outcome
Creators: Jennifer E Hrabe - Department of Surgery, The University of Iowa Hospitals and Clinics, Iowa City, Iowa
John C Byrn
Anna M Button
Gideon K Zamba
Muneera R Kapadia
James J Mezhir
Resource Type: Journal article
Publication Details: Journal of surgical oncology, Vol.109(2), pp.117-121
Publisher: United States
DOI: 10.1002/jso.23465
PMID: 24132737
ISSN: 0022-4790
eISSN: 1096-9098
Language: English
Date published: 02/2014
Academic Unit: Radiology; Biostatistics; Surgery
Record Identifier: 9983997458002771

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