A mathematical model of Bacteroides thetaiotaomicron, Methanobrevibacter smithii, and Eubacterium rectale interactions in the human gut

Melissa A Adrian; Bruce P Ayati; Ashutosh K Mangalam

doi:10.1038/s41598-023-48524-4

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A mathematical model of Bacteroides thetaiotaomicron, Methanobrevibacter smithii, and Eubacterium rectale interactions in the human gut

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A mathematical model of Bacteroides thetaiotaomicron, Methanobrevibacter smithii, and Eubacterium rectale interactions in the human gut

Melissa A Adrian, Bruce P Ayati and Ashutosh K Mangalam

Scientific reports, Vol.13(1), 21192

12/01/2023

DOI: 10.1038/s41598-023-48524-4

PMCID: PMC10692322

PMID: 38040895

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Abstract

The human gut microbiota is a complex ecosystem that affects a range of human physiology. In order to explore the dynamics of the human gut microbiota, we used a system of ordinary differential equations to model mathematically the biomass of three microorganism populations: Bacteroides thetaiotaomicron, Eubacterium rectale, and Methanobrevibacter smithii. Additionally, we modeled the concentrations of relevant nutrients necessary to sustain these populations over time. Our model highlights the interactions and the competition among these three species. These three microorganisms were specifically chosen due to the system’s end product, butyrate, which is a short chain fatty acid that aids in developing and maintaining the intestinal barrier in the human gut. The basis of our mathematical model assumes the gut is structured such that bacteria and nutrients exit the gut at a rate proportional to its volume, the rate of volumetric flow, and the biomass or concentration of the particular population or nutrient. We performed global sensitivity analyses using Sobol’ sensitivities to estimate the relative importance of model parameters on simulation results.

Digestive System

Mathematical Models

Bacteroides thetaiotaomicron

Biomass

Digestive tract

Eubacterium

Intestinal microflora

Methanobrevibacter smithii

Microbiota

Microorganisms

Nutrients

Ordinary differential equations

Sensitivity analysis

Details

Title: Subtitle: A mathematical model of Bacteroides thetaiotaomicron, Methanobrevibacter smithii, and Eubacterium rectale interactions in the human gut
Creators: Melissa A Adrian - University of Iowa
Bruce P Ayati - University of Iowa
Ashutosh K Mangalam - University of Iowa
Resource Type: Journal article
Publication Details: Scientific reports, Vol.13(1), 21192
DOI: 10.1038/s41598-023-48524-4
PMID: 38040895
PMCID: PMC10692322
NLM abbreviation: Sci Rep
eISSN: 2045-2322
Publisher: Nature Publishing Group
Language: English
Date published: 12/01/2023
Academic Unit: Pathology; Iowa Neuroscience Institute; Mathematics
Record Identifier: 9984521375902771

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