A meta-analysis of Hodgkin lymphoma reveals 19p13.3 TCF3 as a novel susceptibility locus

W Cozen; B. K Link; M. N Timofeeva; S Bhatia; J. R Cerhan; D Li; A Diepstra; D Hazelett; M Delahaye-Sourdeix; C. K Edlund; L Franke; K Rostgaard; D. J Van Den Berg; V. K Cortessis; K. E Smedby; S. L Glaser; H. -J Westra; A. E Hwang; L. L Robison; S De Sanjose; T. M Mack; H Ghesquieres; A Nieters; T Lightfoot; N Becker; M Maynadié; L Foretova; E Roman; Y Benavente; K. A Rand; B. N Nathwani; B Glimelius; A Staines; P Boffetta; L Kiemeney; S. M Ansell; L. C Strong; Pilar Galan; L Vatten; T. M Habermann; E. J Duell; A Lake; R. N Veenstra; L Visser; Y Liu; K. Y Urayama; D Montgomery; V Gaborieau; L. M Weiss; G Byrnes; M Lathrop; P Cocco; T Best; A. D Skol; H. -O Adami; M Melbye; A Gallagher; G. M Taylor; S. L Slager; P Brennan; G. A Coetzee; D. V Conti; K Onel; R. F Jarrett; H Hjalgrim; A Van Den Berg; J. D Mckay

doi:10.1038/ncomms4856

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A meta-analysis of Hodgkin lymphoma reveals 19p13.3 TCF3 as a novel susceptibility locus

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A meta-analysis of Hodgkin lymphoma reveals 19p13.3 TCF3 as a novel susceptibility locus

W Cozen, B. K Link, M. N Timofeeva, S Bhatia, J. R Cerhan, D Li, A Diepstra, D Hazelett, M Delahaye-Sourdeix, C. K Edlund, …

Nature communications, Vol.5(1), pp.3856-3856

2014

DOI: 10.1038/ncomms4856

PMCID: PMC4055950

PMID: 24920014

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Abstract

Recent genome-wide association studies (GWAS) of Hodgkin lymphoma (HL) have identified associations with genetic variation at both HLA and non-HLA loci; however, much of heritable HL susceptibility remains unexplained. Here we perform a meta-analysis of three HL GWAS totaling 1,816 cases and 7,877 controls followed by replication in an independent set of 1,281 cases and 3,218 controls to find novel risk loci. We identify a novel variant at 19p13.3 associated with HL (rs1860661; odds ratio (OR) = 0.81, 95% confidence interval (95% CI) = 0.76-0.86, P-combined 3.5 x 10(-10)), located in intron 2 of TCF3 (also known as E2A), a regulator of B-and T-cell lineage commitment known to be involved in HL pathogenesis. This meta-analysis also notes associations between previously published loci at 2p16, 5q31, 6p31, 8q24 and 10p14 and HL subtypes. We conclude that our data suggest a link between the 19p13.3 locus, including TCF3, and HL risk.

Life Sciences

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Title: Subtitle: A meta-analysis of Hodgkin lymphoma reveals 19p13.3 TCF3 as a novel susceptibility locus
Creators: W Cozen - University of Southern California
B. K Link - Carver College of Medicine, University of Iowa
M. N Timofeeva - International Agency for Research on Cancer
S Bhatia - City of Hope National Medical Center
J. R Cerhan - Mayo Clinic
D Li - Cedars-Sinai Medical Center
A Diepstra - University Medical Centre Groningen
D Hazelett - University of Southern California
M Delahaye-Sourdeix - International Agency for Research on Cancer
C. K Edlund - University of Southern California
L Franke - University Medical Centre Groningen
K Rostgaard - Statens seruminstitut
D. J Van Den Berg - University of Southern California
V. K Cortessis - University of Southern California
K. E Smedby - Karolinska Institutet [Stockholm]
S. L Glaser - Cancer Prevention Institute of California
H. -J Westra - University Medical Centre Groningen
A. E Hwang - University of Southern California
L. L Robison - St Jude Children's Research Hospital
S De Sanjose - Bellvitge Biomedical Research Institute
T. M Mack - University of Southern California
H Ghesquieres - Université Claude Bernard Lyon 1
A Nieters - University of Freiburg [Freiburg]
T Lightfoot - University of York
N Becker - German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg]
M Maynadié - Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand
L Foretova - Masaryk Memorial Cancer Institute
E Roman - University of York
Y Benavente - Bellvitge Biomedical Research Institute
K. A Rand - University of Southern California
B. N Nathwani - City of Hope National Medical Center
B Glimelius - Uppsala University
A Staines - Dublin City University
P Boffetta - Icahn School of Medicine at Mount Sinai [New York]
L Kiemeney - Radboud university [Nijmegen]
S. M Ansell - Mayo Clinic
L. C Strong - University of Texas
Pilar Galan - Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité
L Vatten - Norwegian University of Science and Technology
T. M Habermann - Mayo Clinic
E. J Duell - Bellvitge Biomedical Research Institute
A Lake - University of Glasgow
R. N Veenstra - University Medical Centre Groningen
L Visser - University Medical Centre Groningen
Y Liu - University Medical Center Groningen
K. Y Urayama - Tokyo Medical and Dental University
D Montgomery - University of Glasgow
V Gaborieau - International Agency for Research on Cancer
L. M Weiss - Clarient Pathology Services
G Byrnes - International Agency for Research on Cancer
M Lathrop - Genome Québec
P Cocco - University of Cagliari
T Best - University of Chicago
A. D Skol - University of Chicago
H. -O Adami - Harvard University [Cambridge]
M Melbye - Statens seruminstitut
A Gallagher - University of Glasgow
G. M Taylor - School of Cancer Sciences
S. L Slager - Mayo Clinic
P Brennan - International Agency for Research on Cancer
G. A Coetzee - University of Southern California
D. V Conti - University of Southern California
K Onel - University of Chicago
R. F Jarrett - Centre for Virus Research
H Hjalgrim - Statens seruminstitut
A Van Den Berg - University Medical Centre Groningen
J. D Mckay - International Agency for Research on Cancer
Resource Type: Journal article
Publication Details: Nature communications, Vol.5(1), pp.3856-3856
DOI: 10.1038/ncomms4856
PMID: 24920014
PMCID: PMC4055950
NLM abbreviation: Nat Commun
ISSN: 2041-1723
eISSN: 2041-1723
Publisher: Nature Publishing Group
Language: English
Date published: 2014
Academic Unit: Hematology, Oncology, and Blood & Marrow Transplantation; Epidemiology; Internal Medicine
Record Identifier: 9984094352702771

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