Journal article
A meta-analysis of the association of the HOPA12bp polymorphism and schizophrenia
Psychiatric genetics, Vol.16(2), pp.73-76
04/2006
DOI: 10.1097/01.ypg.0000194443.81813.f0
PMID: 16538184
Abstract
Uncommon polymorphisms, particularly balanced uncommon polymorphisms, present a significant challenge to our understanding of their role in behavior. We have recently demonstrated that an uncommon candidate gene polymorphism for schizophrenia, known as HOPA12bp, is the defining polymorphism for a large X-chromosome haplotype in population disequilibrium and that it is associated with a positive syndrome of psychosis. Not all studies, however, have shown this effect. In this report, we reviewed prior studies and conducted meta-analysis of studies using probands of northern European extraction. We found that the presence of the HOPA12bp is a significant risk factor for psychosis for both men and women and suggest that differences in the case definition of schizophrenia may affect the strength of the association.
Details
- Title: Subtitle
- A meta-analysis of the association of the HOPA12bp polymorphism and schizophrenia
- Creators
- Robert A Philibert - Department of Psychiatry, Neuroscience Program, The University of Iowa, Iowa City, IA 52242-1000, USA. robert-philibert@uiowa.edu
- Resource Type
- Journal article
- Publication Details
- Psychiatric genetics, Vol.16(2), pp.73-76
- DOI
- 10.1097/01.ypg.0000194443.81813.f0
- PMID
- 16538184
- NLM abbreviation
- Psychiatr Genet
- ISSN
- 0955-8829
- eISSN
- 1473-5873
- Publisher
- England
- Grant note
- R01 DA015789-01 / NIDA NIH HHS NIH K08MH064714 / NIMH NIH HHS
- Language
- English
- Date published
- 04/2006
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Psychiatry; Iowa Neuroscience Institute
- Record Identifier
- 9984003906702771
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