Journal article
A meta-analytic evaluation of the N2 component as an endophenotype of response inhibition and externalizing psychopathology in childhood
Neuroscience and biobehavioral reviews, Vol.103, pp.200-215
08/2019
DOI: 10.1016/j.neubiorev.2019.06.011
PMID: 31201831
Abstract
•The current systematic review and meta-analysis clarifies the functional meaning the N2 event-related potential component in childhood.•The N2 component was examined with three phenotypes of interest: behavioral response inhibition, self-regulation, and psychopathology.•Findings indicate an association between the N2 and both behavioral response inhibition and externalizing problems.•These findings contribute to our understanding of neural underpinnings of response inhibition and externalizing problems in childhood.
The N2 event-related potential component is a well-studied neurophysiological index of response inhibition that is considered to be a biomarker of externalizing psychopathology. The literature on the N2 elicited in childhood has been inconsistent, though, with different studies yielding different findings regarding the association between the N2 and the constructs it is thought to index. The current meta-analysis sought to clarify the functional meaning of the N2 component elicited in childhood across three widely used response inhibition tasks. The current study meta-analyzed the findings of 54 studies examining the association of the N2 component and three phenotypes of interest: (1) behavioral response inhibition (as indexed by performance on the inhibition trials of the task used to elicit the N2 component), (2) performance on behavioral measures of self-regulation, and (3) psychopathology (both externalizing and internalizing) in samples of children, to clarify the meaning of the N2 component and evaluate its utility as a potential endophenotype. Results suggest that the N2 component is associated with response inhibition and externalizing psychopathology.
Details
- Title: Subtitle
- A meta-analytic evaluation of the N2 component as an endophenotype of response inhibition and externalizing psychopathology in childhood
- Creators
- Caroline P Hoyniak - Indiana University, Department of Psychological and Brain Sciences, 1101 E. 10thStreet A304, Bloomington, IN, 46220, United StatesIsaac T Petersen - University of Iowa, Department of Psychological and Brain Sciences, 308 Iowa Avenue, SLP Room 111, Iowa City, IA, 52242, United States
- Resource Type
- Journal article
- Publication Details
- Neuroscience and biobehavioral reviews, Vol.103, pp.200-215
- Publisher
- Elsevier Ltd
- DOI
- 10.1016/j.neubiorev.2019.06.011
- PMID
- 31201831
- ISSN
- 0149-7634
- eISSN
- 1873-7528
- Grant note
- name: National Science Foundation Graduate Research Fellowship, award: 1342962
- Language
- English
- Date published
- 08/2019
- Academic Unit
- Psychological and Brain Sciences; Iowa Neuroscience Institute; Center for Social Science Innovation
- Record Identifier
- 9984070817802771
Metrics
30 Record Views