Journal article
A meta-analytic investigation of linkage and association of common leptin receptor (LEPR) polymorphisms with body mass index and waist circumference
International journal of obesity, Vol.26(5), pp.640-646
2002
DOI: 10.1038/sj.ijo.0801990
PMID: 12032747
Abstract
METHOD: We analyzed data pooled from nine studies on the human leptin receptor (LEPR) gene for the association of three alleles (K1O9R, Q223R and K656N) of LEPR with body mass index (BMI; kg/m2) and waist circumference (WC). A total of 3263 related and unrelated subjects from diverse ethnic backgrounds including African-American, Caucasian, Danish, Finnish, French Canadian and Nigerian were studied. We tested effects of individual alleles, joint effects of alleles at multiple loci, epistatic effects among alleles at different loci, effect modification by age, sex, diabetes and ethnicity, and pleiotropic genotype effects on BMI and WC. RESULTS: We found that none of the effects were significant at the 0.05 level. Heterogeneity tests showed that the variations of the non-significant effects are within the range of sampling variation. CONCLUSION: We conclude that, although certain genotypic effects could be population-specific, there was no statistically compelling evidence that any of the three LEPR alleles is associated with BMI or WC in the overall population.
Details
- Title: Subtitle
- A meta-analytic investigation of linkage and association of common leptin receptor (LEPR) polymorphisms with body mass index and waist circumference
- Creators
- M Heo - St. Luke's-Roosevelt Hospital CenterR. L Leibel - University of AlabamaM. I. J Uusitupa - Department of Medicine, University of Knopio, Kuopio, FinlandY Chagnon - University of AlabamaC Bouchard - Pennington Biomedical Research CenterP. A Donohoue - University of AlabamaT. L Burns - University of IowaA. R Shuldiner - University of Maryland, BaltimoreK Silver - University of Maryland, BaltimoreR. E Andersen - Johns Hopkins UniversityO Pedersen - University of AlabamaS Echwald - University of AlabamaK. R Fontaine - Johns Hopkins UniversityT. I. A Sørensen - University of CopenhagenP Behn - Internal Medicine AssociatesM. A Permutt - Washington University in St. LouisK. B Jacobs - Case Western Reserve UniversityR. C Elston - Case Western Reserve UniversityD. J Hoffman - Rutgers, The State University of New JerseyE Gropp - University of AlabamaD. B Allison - University of Alabama at BirminghamB. B Boyer - University of Alaska FairbanksW. K Chung - Columbia UniversityM Koulu - University of AlabamaM. K Karvonen - University of AlabamaU Pesonen - University of AlabamaA Rissanen - University of HelsinkiM Laakso - Finland University
- Resource Type
- Journal article
- Publication Details
- International journal of obesity, Vol.26(5), pp.640-646
- Publisher
- Nature Publishing
- DOI
- 10.1038/sj.ijo.0801990
- PMID
- 12032747
- ISSN
- 0307-0565
- eISSN
- 1476-5497
- Language
- English
- Date published
- 2002
- Academic Unit
- Epidemiology; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9984363619002771
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