Journal article
A method for MRI-guided bronchoscopy to identify obstructed airway segments
Physiological reports, Vol.13(4), e70119
02/2025
DOI: 10.14814/phy2.70119
PMCID: PMC11842447
PMID: 39980176
Appears in UI Libraries Support Open Access
Abstract
Bronchoscopy is not conventionally guided by prior knowledge of segmental airway obstruction. Hyperpolarized gas magnetic resonance imaging (MRI) ventilation abnormalities and computed tomography (CT) air trapping are related to lung function and asthma severity but have not been used to target segmental inflammation and remodeling. We evaluate the feasibility of using bronchoscopy guided by
He MRI and CT to reveal differences in inflammatory response, morphology, and cellular activity in poorly- (defect) versus well-ventilated (control) lung regions. Eleven participants (5 female; age, 22.8 ± 3.4 years; 9 asthma) who experienced a cold with increased lower airway symptoms underwent
He MRI and/or CT at least 6 weeks after recovery. Differences between defect and control regions were compared. In defect as compared to control sites, bronchoalveolar lavage neutrophils (p = 0.06) and granulocytes (p = 0.08) trended towards an increase; inflammatory mediators (i.e., 15-epi-LXA4, LXA4) were also significantly different (p < 0.05) between sites. Correlations were observed between macrophages, neutrophils, and eosinophils with inflammatory mediators (i.e., 15-epi-LXA4, LXA4, LTB4). Correlations were observed for macrophages and neutrophils with 15-epi-LXA4, and eosinophils with LXA4 and leukotriene B4. Basement membrane wall thickness was similar for defect versus control sites (p = 0.9). These results support the feasibility of image-guided methods to identify airway obstruction phenotypes.
Details
- Title: Subtitle
- A method for MRI-guided bronchoscopy to identify obstructed airway segments
- Creators
- David G Mummy - Duke Medical CenterMarrissa J McIntosh - University of IowaKatherine J Carey - University of Wisconsin–MadisonShannon Kehoe - University of Wisconsin–MadisonStephane Esnault - University of Wisconsin–MadisonMats W Johansson - University of Wisconsin–MadisonMichael D Evans - University of MinnesotaRonald L Sorkness - University of Wisconsin–MadisonMark Schiebler - University of Wisconsin–MadisonNizar N Jarjour - University of Wisconsin–MadisonLoren C Denlinger - University of Wisconsin–MadisonSean B Fain - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Physiological reports, Vol.13(4), e70119
- DOI
- 10.14814/phy2.70119
- PMID
- 39980176
- PMCID
- PMC11842447
- NLM abbreviation
- Physiol Rep
- ISSN
- 2051-817X
- eISSN
- 2051-817X
- Publisher
- Wiley
- Grant note
- HL115118 / HHS | National Institutes of Health (NIH) HL126771 / HHS | National Institutes of Health (NIH) HL080412 / HHS | National Institutes of Health (NIH) HL146689 / HHS | National Institutes of Health (NIH) HL169765 / HHS | National Institutes of Health (NIH) UL1RR025011 / National Center for Advancing Translational Sciences (NCATS) William W. and Judith H. Busse Professorship in Allergy and Asthma Research
- Language
- English
- Date published
- 02/2025
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Electrical and Computer Engineering; Health, Sport, and Human Physiology
- Record Identifier
- 9984790995202771
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