Journal article
A method for in-vivo analysis for regional arterial wall material property alterations with atherosclerosis: preliminary results
Medical engineering & physics, Vol.25(4), pp.289-298
2003
DOI: 10.1016/S1350-4533(02)00224-2
PMID: 12649013
Abstract
Atherosclerosis is a diffuse arterial disease developing over many years and resulting in a complicated three-dimensional arterial morphology. The arterial wall material properties have been demonstrated to show regional alterations with atheroma development and growth. We present a mechanical analysis of diseased arterial segments reconstructed from intravascular ultrasound images in order to quantitatively identify regional alterations in the elastic constants with atherosclerotic lesions. We employ a finite element and a displacement sensitivity analysis to divide the arterial segment into regions with different material properties and use an optimization algorithm to identify the elastic constants in these regions. The results with regional variations identified with this method correlated qualitatively with the extent and location of atherosclerotic lesions identified by visual inspection of the affected arteries. The optimized elastic modulus in regions affected by early atherosclerotic lesions ranged from 90.9 to 93.0 kPa where as the corresponding magnitudes in normal arterial segments ranged from 97.9 to 101.0 kPa. This method can be potentially employed to identify the extent and location of atherosclerotic lesions in a systematic analysis and may potentially be used for the early detection of lesion growth.
Details
- Title: Subtitle
- A method for in-vivo analysis for regional arterial wall material property alterations with atherosclerosis: preliminary results
- Creators
- K.B Chandran - Department of Biomedical Engineering, University of Iowa, 1402 SC, Iowa City, Iowa, USAJ.H Mun - Department of Biomedical Engineering, University of Iowa, 1402 SC, Iowa City, Iowa, USAK.K Choi - Department of Mechanical Engineering and Center for Computer-Aided Design, University of Iowa, 1402 SC, Iowa City, Iowa, USAJ.S Chen - Department of Mechanical Engineering and Center for Computer-Aided Design, University of Iowa, 1402 SC, Iowa City, Iowa, USAA Hamilton - Department of Internal Medicine and Feinberg Cardiovascular Research Institute, Northwestern University Medical School, Chicago, Illinois, USAA Nagaraj - Department of Internal Medicine and Feinberg Cardiovascular Research Institute, Northwestern University Medical School, Chicago, Illinois, USAD.D McPherson - Department of Internal Medicine and Feinberg Cardiovascular Research Institute, Northwestern University Medical School, Chicago, Illinois, USA
- Resource Type
- Journal article
- Publication Details
- Medical engineering & physics, Vol.25(4), pp.289-298
- Publisher
- Elsevier Ltd
- DOI
- 10.1016/S1350-4533(02)00224-2
- PMID
- 12649013
- ISSN
- 1350-4533
- eISSN
- 1873-4030
- Language
- English
- Date published
- 2003
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Mechanical Engineering
- Record Identifier
- 9984064222002771
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