Journal article
A method to determine activation thresholds in fMRI paradigms
Psychiatry research. Neuroimaging, Vol.75(1), pp.15-22
08/08/1997
DOI: 10.1016/S0925-4927(97)00024-3
PMID: 9287370
Abstract
Determining meaningful activation thresholds in functional magnetic resonance imaging (fMRI) paradigms is complicated by several factors. These include the time-series nature of the data, the influence of physiological rhythms (e.g. respiration) and vacillations introduced by the experimental design (e.g. cueing). We present an empirical threshold for each subject and each fMRI experiment that takes these factors into account. The method requires an additional fMRI data set as similar to the experimental paradigm as possible without dichotomously varying the experimental task of interest. A letter fluency task was used to illustrate this method. This technique differs from classical methods since the Pearson correlation probability values tabulated from statistical theory are not used. Rather, each subject defines his or her own set of threshold probability values for correlations. It is against these empirical thresholds, not Pearson's, that an experimental fMRI correlation is assessed.
Details
- Title: Subtitle
- A method to determine activation thresholds in fMRI paradigms
- Creators
- Stephan Arndt - University of IowaSherri Gold - University of IowaTed Cizadlo - University of IowaJie Zheng - University of IowaJames C. Ehrhardt - University of IowaMichael Flaum - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Psychiatry research. Neuroimaging, Vol.75(1), pp.15-22
- DOI
- 10.1016/S0925-4927(97)00024-3
- PMID
- 9287370
- NLM abbreviation
- Psychiatry Res Neuroimaging
- ISSN
- 0925-4927
- eISSN
- 1872-7506
- Publisher
- Elsevier Ireland Ltd
- Number of pages
- 8
- Language
- English
- Date published
- 08/08/1997
- Academic Unit
- Radiology; Psychiatry; Biostatistics; Nursing; Injury Prevention Research Center
- Record Identifier
- 9985132073002771
Metrics
1 Record Views