A methodology for incorporating functional bone marrow sparing in IMRT planning for pelvic radiation therapy

Sarah M McGuire; Yusuf Menda; Laura L Boles Ponto; Brandie Gross; Malik Juweid; John E Bayouth

doi:10.1016/j.radonc.2011.01.025

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A methodology for incorporating functional bone marrow sparing in IMRT planning for pelvic radiation therapy

Journal article

Peer reviewed

A methodology for incorporating functional bone marrow sparing in IMRT planning for pelvic radiation therapy

Sarah M McGuire, Yusuf Menda, Laura L Boles Ponto, Brandie Gross, Malik Juweid and John E Bayouth

Radiotherapy and oncology, Vol.99(1), pp.49-54

2011

DOI: 10.1016/j.radonc.2011.01.025

PMID: 21397965

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Abstract

The purpose of this study was to design a radiation therapy treatment planning approach that would spare hematopoietically active bone marrow using [ 18F]FLT PET imaging. We have developed an IMRT planning methodology to incorporate functional PET imaging using [ 18F]FLT scans. Plans were generated for two simulated cervical cancer patients, where pelvic active bone marrow regions were incorporated as avoidance regions based on the ranges: SUV4 ⩾ 4; 4 > SUV3 ⩾ 3; and 3 > SUV2 ⩾ 2. Dose objectives were set to reduce bone marrow volume that received 10 ( V 10) and 20 ( V 20) Gy. Active bone marrow regions identified by [ 18F]FLT with an SUV ⩾ 2, SUV ⩾ 3, and SUV ⩾ 4 represented an average of 43.0%, 15.3%, and 5.8%, respectively of the total osseous pelvis for the two cases studied. Improved dose–volume histograms for all identified bone marrow SUV volumes and decreases in V 10, and V 20 were achieved without clinically significant changes to PTV or OAR doses. Incorporation of [ 18F]FLT PET in IMRT planning provides a methodology to reduce radiation dose to active bone marrow without compromising PTV or OAR dose objectives in pelvic malignancies.

Bone marrow

IMRT

[ 18F]FLT PET

Cervical cancer

Details

Title: Subtitle: A methodology for incorporating functional bone marrow sparing in IMRT planning for pelvic radiation therapy
Creators: Sarah M McGuire - Department of Radiation Oncology , University of Iowa Hospitals and Clinics, Iowa City, USA and
Yusuf Menda - Department of Radiology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA
Laura L Boles Ponto - Department of Radiology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA
Brandie Gross - Department of Radiation Oncology , University of Iowa Hospitals and Clinics, Iowa City, USA and
Malik Juweid - Department of Radiology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA
John E Bayouth - Department of Radiation Oncology , University of Iowa Hospitals and Clinics, Iowa City, USA and
Resource Type: Journal article
Publication Details: Radiotherapy and oncology, Vol.99(1), pp.49-54
DOI: 10.1016/j.radonc.2011.01.025
PMID: 21397965
NLM abbreviation: Radiother Oncol
ISSN: 0167-8140
eISSN: 1879-0887
Publisher: Elsevier Ireland Ltd
Language: English
Date published: 2011
Academic Unit: Radiology; Pharmaceutical Sciences and Experimental Therapeutics; Radiation Oncology
Record Identifier: 9984046824002771

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