Journal article
A modified microfluidic chip for fabrication of paclitaxel-loaded poly(l-lactic acid) microspheres
Microfluidics and nanofluidics, Vol.10(6), pp.1289-1298
06/01/2011
DOI: 10.1007/s10404-010-0760-7
Abstract
In this article, we present a simple PDMS surface modification method based on poly(vinyl alcohol)/glycerol (PVA/Gly) solution immersion, self-assembled absorption, and heat treatment. The results of contact angle and ATR-FTIR demonstrate the superhydrophilic surface in modified PDMS. It can allow for the stable production of monodisperse droplet in a highly reproducible manner. In addition, we demonstrate the fabrication of monodisperse paclitaxel (PTX) loaded poly(l-lactic acid) (PLLA) microspheres on this kind of modification chip with solvent evaporation. The PLLA microspheres can be adjusted to a range of different sizes depending on the system flow rate. Determination of microsphere size is carried out by optical microscopy and image analysis to reveal less than 4% variation in microsphere size. Compared with the results of published papers, the presented data demonstrate that PTX-loaded PLLA microspheres show good physical properties (spherical and discrete), high-drug loading, encapsulation efficiency, a small initial burst, and sustained-release behavior due to outstanding monodispersity. With the characteristic to prepare high-quality, monodisperse, biodegradable microspheres, the versatile and simple microfluidic method facilitates the development of more reliable and reproducible drug delivery systems, which have great potential to benefit pharmaceutical and biological applications.
Details
- Title: Subtitle
- A modified microfluidic chip for fabrication of paclitaxel-loaded poly(l-lactic acid) microspheres
- Creators
- Tianxi He - Tsinghua UniversityQionglin Liang - Tsinghua UniversityKai Zhang - East China University of Science and TechnologyXuan Mu - East China University of Science and TechnologyTingting Luo - East China University of Science and TechnologyYiming Wang - Tsinghua UniversityGuoan Luo - Tsinghua University
- Resource Type
- Journal article
- Publication Details
- Microfluidics and nanofluidics, Vol.10(6), pp.1289-1298
- Publisher
- Springer Nature
- DOI
- 10.1007/s10404-010-0760-7
- ISSN
- 1613-4982
- eISSN
- 1613-4990
- Number of pages
- 10
- Grant note
- 20080031012 / Ministry of Education of China; Ministry of Education, China 2007CB714505 / National Basic Research Program (973 Program) of China; National Basic Research Program of China 2009ZX09311-01 / National Major Special Project of Science and Technology
- Language
- English
- Date published
- 06/01/2011
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering
- Record Identifier
- 9984276455002771
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