Journal article
A molecular basis for interactions between sleep and memory
Sleep medicine clinics, Vol.6(1), pp.71-84
03/01/2011
DOI: 10.1016/j.jsmc.2010.12.004
PMCID: PMC3040954
PMID: 21339852
Abstract
The electrophysiological properties of the sleeping brain profoundly influence memory function in various species, yet the molecular nature by which sleep and memory interact remains unclear. We summarize work that has established the cAMP-PKA-CREB intracellular signaling pathway as a major mechanism involved in the wakeful consolidation of memory in many organisms while highlighting newer evidence that this pathway has a role in sleep regulation, sleep deprivation and potentially sleep-memory interactions. We explore the possibility that sleep might influence memory processing by reactivating the same molecular cascades first recruited during learning during a sort of “molecular replay”. Lastly, we discuss how new approaches together with established techniques will aid in our understanding of the nature of sleep-memory interactions.
Details
- Title: Subtitle
- A molecular basis for interactions between sleep and memory
- Creators
- Pepe J Hernandez - Department of Biology, University of Pennsylvania, Philadelphia, PATed Abel - Department of Biology, University of Pennsylvania, Philadelphia, PA
- Resource Type
- Journal article
- Publication Details
- Sleep medicine clinics, Vol.6(1), pp.71-84
- DOI
- 10.1016/j.jsmc.2010.12.004
- PMID
- 21339852
- PMCID
- PMC3040954
- NLM abbreviation
- Sleep Med Clin
- ISSN
- 1556-407X
- eISSN
- 1556-4088
- Language
- English
- Date published
- 03/01/2011
- Academic Unit
- Molecular Physiology and Biophysics; Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute; Neuroscience and Pharmacology; Biochemistry and Molecular Biology
- Record Identifier
- 9984065734302771
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